{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:14:41Z","timestamp":1790036081946,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Programmed death-ligand 1 (PD-L1) expression in some tumors has prognostic implications. This work aims at investigating PD-L1 expression in diffuse large B-cell lymphoma (DLBCL) and to study its association with clinicopathological variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study consisted of 75 DLBCL patients who were cared for at the King Hussein Cancer Center during the period 2015\u20132018. The expression of PD-L1 in tumor tissue was assessed by immunohistochemistry using the anti-human PD-L1 (Clone 22C3) monoclonal antibody. The correlation between gender, age, clinical stage, pre-treatment-LDH level, tumor location, response to therapy, overall and event-free survival with PD-L1 expression was studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six patients were excluded from further analysis as they were in relapse at the time of tissue sampling. The tumor proportion score (TPS) was \u22651% in 16\/69 (23.2%) of DLBCL cases while the combined positive score (CPS) at a cut-off of \u226520 was observed in 23\/69 (33.3%) cases. No significant difference in PD-L1 expression was found between germinal center B-cell-like (GCB) and non-GCB subtypes. Similarly, no differences in PD-L1 expression (at CPS \u226520 and TPS \u22651) were found between different genders, age groups, clinical stages, tumor location, and patient response to therapy. However, base-line lactate dehydrogenase was significantly elevated in patients with PD-L1 CPS \u226520. The overall survival was not significantly different between PD-L1-positive and -negative groups. On the other hand, the median event-free survival was higher in either of the PD-L1 TPS or CPS negative groups at 107months each versus 54 months in the PD-L1 positive group of either category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PD-L1 expression can predict event-free survival in DLBCL cases and therefore poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155221149749","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T03:23:09Z","timestamp":1673234589000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Programmed death-ligand 1 expression in diffuse large B-cell lymphoma is associated with poor prognosis"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-0833","authenticated-orcid":false,"given":"Esraa","family":"Al-Khateeb","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan"},{"name":"Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal A.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan"},{"name":"Pharmacological and Diagnostic Research Lab., Al-Ahliyya Amman University, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd B.","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-9616","authenticated-orcid":false,"given":"Maher A.","family":"Sughayer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"bibr1-03936155221149749","first-page":"362","author":"Al-Naeeb AB","year":"2018","journal-title":"Br Med J"},{"key":"bibr2-03936155221149749","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr3-03936155221149749","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0963-1"},{"key":"bibr4-03936155221149749","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2837"},{"key":"bibr5-03936155221149749","volume-title":"Cancer incidence in five continents, Vol. XI. 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