{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:39:28Z","timestamp":1782441568086,"version":"3.54.5"},"reference-count":45,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82200208"],"award-info":[{"award-number":["No. 82200208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Municipal Education Commission Foundation","award":["Grant 2019KJ187"],"award-info":[{"award-number":["Grant 2019KJ187"]}]},{"name":"Tianjin Municipal Science and Technology Project","award":["Grant 20JCYBJC00110"],"award-info":[{"award-number":["Grant 20JCYBJC00110"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Upstream stimulatory factors ( USFs) are members of the basic helix-loop-helix leucine zipper transcription factor family, including USF1, USF2, and USF3. The first two members have been well studied compared to the third member, USF3, which has received scarce attention in cancer research to date. Despite a recently reported association of its alteration with thyroid carcinoma, its expression has not been previously analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We comprehensively analyzed differential levels of USFs expression, genomic alteration, DNA methylation, and their prognostic value across different cancer types and the possible correlation with tumor-infiltrating immune cells and drug response by using different bioinformatics tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings established that USFs play an important role in cancers related to the urinary system and justify the necessity for further investigation. We implemented and offer a useful ShinyApp to facilitate researchers\u2019 efforts to inquire about any other gene of interest and to perform the analysis of drug response in a user-friendly fashion at http:\/\/zzdlab.com:3838\/Drugdiscovery\/ .<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155231206135","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:11:36Z","timestamp":1697512296000},"page":"243-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Systematic analysis reveals distinct roles of USF family proteins in various cancer types"],"prefix":"10.1177","volume":"38","author":[{"given":"Xia","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's clinical 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