{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:17:43Z","timestamp":1778645863030,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Radiation-induced trismus (RIT), one of the rare but serious side effects of concurrent chemoradiotherapy (C-CRT), is difficult to predict with high accuracy. We aimed to examine whether the pretreatment pan-immune-inflammation value (PIV) measures predict RIT in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving C-CRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of patients with LA-NPC who underwent C-CRT and had maximum mouth openings (MMO)\u2009&gt;\u200935\u2005mm were reviewed. Any MMO of 35\u2005mm or less after C-CRT was considered RIT. All PIV values were computed using the complete blood count test results: PIV\u2009=\u2009(Platelets\u2009\u00d7\u2009Monocytes\u2009\u00d7\u2009Neutrophils) \u00f7 Lymphocytes. The receiver operating characteristic analysis was employed to dissect a possible association between pre-treatment PIV readings and RIT status. Confounding variables were tested for their independent relationship with the RIT rates using logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The research comprised 223 participants, and RIT was diagnosed in 46 (20.6%) at a median time from C-CRT to RIT of 10 months (range: 5\u201318 months). Pre-C-CRT PIV levels and RIT rates were analyzed using receiver operating characteristic curve analysis, with 830 being the optimal cutoff (area under the curve: 92.1%; sensitivity: 87.5%; specificity: 85.5%; Youden index: 0.730). RIT was significantly more prevalent in the PIV\u2009&gt;\u2009830 cohort than its PIV\u2009\u2264\u2009830 counterpart (60.3% vs. 5%; hazard ratio 5.79; P\u2009&lt;\u20090.001). Multivariate logistic regression analysis revealed that advanced T-stage ( P\u2009=\u20090.004), masticatory apparatus dose V58Gy\u2265%32 ( P\u2009=\u20090.003), and PIV\u2009&gt;\u2009830 ( P\u2009&lt;\u20090.001) were independently linked with significantly elevated rates of RIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of elevated pre-C-CRT PIV is a unique biological marker that independently predicts increased RIT rates in LA-NPC undergoing C-CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155231223198","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T01:45:38Z","timestamp":1704764738000},"page":"80-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Worth of pan-immune-inflammation value in trismus prediction after concurrent chemoradiotherapy for nasopharyngeal carcinomas"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8251-6913","authenticated-orcid":false,"given":"Efsun","family":"Somay","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey"},{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Kyrenia, Kyrenia, North Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busra","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dental Medicine, Bahcesehir University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2218-2074","authenticated-orcid":false,"given":"Erkan","family":"Topkan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Baskent University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyza Sirin","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Clinics of Radiation Oncology, Medical Park Hospital, \rAntalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duriye","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Ayberk","family":"Besen","sequence":"additional","affiliation":[{"name":"Clinics of Medical Oncology, Adana Medical Park Hospital, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Mertsoylu","sequence":"additional","affiliation":[{"name":"Clinics of Medical Oncology, Istinye University, Adana Medical Park Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Selek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, 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