{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:30:22Z","timestamp":1793727022161,"version":"4.6.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Suqian Talent Work Leading Group","award":["20220049"],"award-info":[{"award-number":["20220049"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-muscle invasive bladder cancer (NMIBC) is the most prevalent type of bladder cancer, typically associated with a favorable prognosis and a risk of recurrence during the follow-up period. Inflammatory markers have been used to predict prognosis in various cancer types. The aim of this study was to explore the prognostic value of the readily accessible inflammatory markers, platelet-to-lymphocyte ratio (PLR) and interleukin-6 (IL-6), in NMIBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study comprised a retrospective analysis of clinical data collected from NMIBC patients diagnosed between October 2018 and October 2020. PLR was calculated using the routine preoperative blood test results, and preoperative IL-6 levels were recorded. Receiver operating characteristic (ROC) curves were generated for PLR and IL-6 level and the optimal cut-off values were determined using Youden's index. Survival curves were generated to evaluate the association between PLR and IL-6, and recurrence-free survival (RFS), and univariate and multivariate analysis were performed using the Cox proportional hazards regression model. A nomogram and calibration curve were generated to assess the clinical significance of the model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ROC curves demonstrated that PLR and IL-6 levels were significantly associated with tumor pathology grade, with area under the curve (AUC) values of 0.833 (95% CI 0.757, 0.910) for PLR and 0.724 (95% CI 0.622, 0.825) for IL-6 levels. PLR and IL-6 levels were also positively associated with tumor recurrence, with AUC values of 0.647 (95% CI 0.538, 0.756) and 0.846 (95% CI 0.769, 0.924), respectively. The survival curves indicated that patients with high PLR and high IL-6 levels had shorter RFS than those with low PLR and low IL-6 level ( P\u2009&lt;\u20090.01). Univariate Cox proportional hazards regression analysis showed that age, tumor size, tumor number, pathological grade, PLR and IL-6 were potential risk factors for NMIBC recurrence. Multivariate analysis further revealed that tumor number, smoking, PLR, and IL-6 were independent risk factors for NMIBC recurrence ( P\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative peripheral blood inflammatory markers (PLR and IL-6) are useful predictors of RFS in NMIBC patients at the time of initial diagnosis. High PLR and high IL-6 were identified as independent risk factors for tumor recurrence and could serve as potential biological markers for prediction of NMIBC recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155241261719","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T03:49:13Z","timestamp":1718077753000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The prognostic significance of preoperative platelet-to-lymphocyte ratio and interleukin-6 level in non-muscle invasive bladder cancer"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5805-8875","authenticated-orcid":false,"given":"Xiangyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Surgery, Nanjing Drum-Tower Hospital Group Suqian Hospital, The Affiiated Suqian Hospital of Xuzhou Medical University, Suqian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, Nanjing Drum-Tower Hospital Group Suqian Hospital, The Affiiated Suqian Hospital of Xuzhou Medical University, Suqian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, Nanjing Drum-Tower Hospital Group Suqian Hospital, The Affiiated Suqian Hospital of Xuzhou Medical University, Suqian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, Nanjing Drum-Tower Hospital Group Suqian Hospital, The Affiiated Suqian Hospital of Xuzhou Medical University, Suqian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, Nanjing Drum-Tower Hospital Group Suqian Hospital, The Affiiated Suqian Hospital of Xuzhou Medical University, Suqian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"bibr1-03936155241261719","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"bibr2-03936155241261719","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.05.015"},{"key":"bibr3-03936155241261719","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28252"},{"key":"bibr4-03936155241261719","volume":"97","author":"Wang H","year":"2018","journal-title":"Medicine 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