{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:42:02Z","timestamp":1777790522402,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["CO-2018-12367051"],"award-info":[{"award-number":["CO-2018-12367051"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PNRR-MAD-2022-12375663"],"award-info":[{"award-number":["PNRR-MAD-2022-12375663"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente grant L3\/13"],"award-info":[{"award-number":["Ricerca Corrente grant L3\/13"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2016 \u2013ID. 18921"],"award-info":[{"award-number":["IG 2016 \u2013ID. 18921"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2021 \u2013 ID. 25932"],"award-info":[{"award-number":["IG 2021 \u2013 ID. 25932"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG2020 - ID 25179"],"award-info":[{"award-number":["IG2020 - ID 25179"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic processes and their prognostic value in large patient cohorts is still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, by using immunohistochemistry followed by digital pathology, we investigated the expression of several markers related to glycolysis including monocarboxylate transporter 1 and 4 (MCT1, MCT4), glutamine metabolism (glutaminase, GLS) and hypoxia\/acidosis (carbonic anhydrase 9, CA IX) in tissue microarrays of &gt; 300 patients recruited in the MITO16A clinical trial, which involved treatment of ovarian cancer patients with carboplatin\/taxol plus bevacizumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regarding the prognostic impact of these markers, results indicate that GLS expression correlated with progression-free survival, but this effect disappeared when data were corrected for multiple testing. All other markers showed no correlation with clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate marked heterogeneity of expression of metabolism-associated markers in ovarian cancer; however, there was a lack of association with clinical benefit after chemotherapy\/anti-vascular endothelial growth factor treatment. Notwithstanding the lack of prognostic value, knowledge of the pattern of expression of these biomarkers in tumors can be useful for patient stratification purposes when new drugs targeting these metabolic pathways will be tested.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155241296164","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:33:49Z","timestamp":1731040429000},"page":"328-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A\/MaNGO-OV2 trial"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-7136","authenticated-orcid":false,"given":"Stefano","family":"Indraccolo","sequence":"first","affiliation":[{"name":"Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Signoriello","sequence":"additional","affiliation":[{"name":"Medical Statistics Unit, Department of Physical and Mental Health and Preventive Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Piga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[{"name":"Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-2123","authenticated-orcid":false,"given":"Federica","family":"Ferrarini","sequence":"additional","affiliation":[{"name":"Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-0814","authenticated-orcid":false,"given":"Andrea","family":"Boscolo Bragadin","sequence":"additional","affiliation":[{"name":"Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanda","family":"Salutari","sequence":"additional","affiliation":[{"name":"Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy, Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Pisano","sequence":"additional","affiliation":[{"name":"Uro-Gynecological Medical Oncology, Istituto Nazionale Tumori, IRCCS-Fondazione G. 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