{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:42:55Z","timestamp":1777790575320,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shanghai Municipal Health Commission: A Study on the Risk Assessment and Prognostic Comprehensive Model of Lymph Node Metastasis in Thyroid Papillary Microcancer with Multi Model\/Multi Feature Fusion","award":["20214Y0223"],"award-info":[{"award-number":["20214Y0223"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The papillary thyroid cancer (PTC) incidence is on the increase. We explored the diagnostic value of microRNA (miR)-129-5p &amp; serologic indicator thyroid-stimulating hormone (TSH) test in PTC with cervical lymph node metastasis (LNM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>According to the pathological \u201cgold standard,\u201d 198 PTC patients were assigned into the LNM (n\u2009=\u200993)\/non-LNM (n\u2009=\u2009105) groups, with their medical records collected. The serum free-triiodothyronine (FT3)\/free-thyroxine (FT4)\/TSH\/thyroglobulin (Tg)\/thyroglobulin antibody levels were assessed using an electrochemiluminescence immunoassay device. Serum miR-129-5p expression was determined by reverse transcription quantitative polymerase chain reaction. Correlations between serum miR-129-5p\/TSH levels with pathological indicators were analyzed by Spearman correlation coefficient. Independent influencing factors for cervical LNM in PTC patients was analyzed by logistic multivariate regression analysis. Diagnostic value of miR-129-5p combined with serologic indicator TSH test in PTC patients with cervical LNM and lateral cervical LNM was analyzed by the receiver operating characteristic curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The two groups varied obviously in primary tumor size\/Tg level. Serum miR-129-5p expression in the LNM group was reduced, and negatively correlated with Tg and primary tumor size, while the serologic indicator TSH level showed positive correlations with Tg and primary tumor size. Independent influencing factors for PTC with cervical LNM were miR-129-5p\/TSH\/Tg levels. miR-129-5p and serologic indicator TSH levels had high diagnostic value for PTC patients with cervical LNM and lateral cervical LNM, with their combination showing higher diagnostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miR-129-5p and serologic indicator TSH had high diagnostic value for diagnosing PTC patients with cervical LNM, providing high reference value for the formulation of thyroid tumor resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155241303763","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T13:35:22Z","timestamp":1741095322000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic value of microRNA-129-5p and TSH combination for papillary thyroid cancer with cervical lymph node metastasis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0062-5344","authenticated-orcid":false,"given":"Yi","family":"Shen","sequence":"first","affiliation":[{"name":"Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongli","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xujie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-en","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0418-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29912"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480507100907"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15388"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.5.489"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.246"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-019-00485-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1724600820985528"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17176-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.937049"},{"key":"e_1_3_3_13_2","first-page":"126","article-title":"Relationship between thyroid-stimulating hormone level and aggressive pathological features of papillary thyroid cancer","volume":"56","author":"Demircioglu ZG","year":"2022","unstructured":"Demircioglu ZG, Demircioglu MK, Aygun N, et al. 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