{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:52:42Z","timestamp":1793253162216,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between serum uric acid and breast cancer remains uncertain. This meta-analysis aimed to elucidate the dose-response association between elevated serum uric acid levels and breast cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, and Web of Science for observational studies evaluating serum uric acid and breast cancer risk in adult women. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies were included. High serum uric acid was associated with an increased breast cancer risk (RR: 1.34; 95% CI: 1.03\u20131.73;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.03; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200978%). Meta-regression analysis revealed that the cutoff for high serum uric acid positively correlated with breast cancer risk (coefficient\u2009=\u20090.24;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), explaining heterogeneity (residual I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Subgroup analysis demonstrated a high serum uric acid was significantly related to an increased breast cancer risk in studies with a cutoff value\u2009\u2265\u20095.4\u2005mg\/dL (RR: 1.95;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not in those with a cutoff value\u2009&lt;\u20095.4\u2005mg\/dL (RR: 0.97;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.44). The dose-response meta-analysis revealed a U-shaped association between serum uric acid levels and the risk of breast cancer (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for nonlinearity\u2009=\u20090.013). The risk of breast cancer fell until around 4.5\u2005mg\/dL of serum uric acid, and increased afterward.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum uric acid may be nonlinearly associated with the risk of breast cancer (U-shaped). The risk of breast cancer increases with serum uric acid above 4.5\u2005mg\/dL, and a higher association between serum uric acid and the increased risk of breast cancer could be observed in studies with cutoff of serum uric acid \u2009&gt;\u20095.4\u2005mg\/dL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155241313469","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:29:58Z","timestamp":1740108598000},"page":"35-45","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between serum uric acid and the risk of breast cancer: A meta-analysis of observational studies"],"prefix":"10.1177","volume":"40","author":[{"given":"Liping","family":"Yang","sequence":"first","affiliation":[{"name":"Jiangxi Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyun","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangxi Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangxi Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbo","family":"He","sequence":"additional","affiliation":[{"name":"Jiangxi Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3160-5155","authenticated-orcid":false,"given":"Qingfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Jiangxi Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.2996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12207"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","DOI":"10.3390\/diseases12060111","article-title":"Prognostic factors associated with breast cancer-specific survival from 1995 to 2022: A systematic review and meta-analysis of 1,386,663 cases from 30 countries","volume":"12","author":"Abdul Rahman H","year":"2024","unstructured":"Abdul Rahman H, Zaim SNN, Suhaimei US, et al. 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