{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:20:25Z","timestamp":1781101225848,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    Oral squamous cell carcinoma (OSCC) is a malignant neoplasm with high mortality and recurrence. Its etiology is multifactorial and involves environmental factors such as smoking, alcohol, and human papilloma virus infection, as well as genetic factors such as single nucleotide polymorphisms. The\n                    <jats:italic toggle=\"yes\">fractalkine<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">CX3CR1<\/jats:italic>\n                    axis is key in the regulation of cell apoptosis, proliferation, migration, and invasion, which are fundamental processes in cancer development. The\n                    <jats:italic toggle=\"yes\">CX3CL1<\/jats:italic>\n                    gene, which encodes fractalkine, presents variants such as rs223815 (G\u2009&gt;\u2009C) and rs682082 (G\u2009&gt;\u2009A), associated with resistance to chemotherapy in ovarian cancer. In OSCC, its increased expression correlates with shorter survival. On the other hand, the\n                    <jats:italic toggle=\"yes\">CX3CR1<\/jats:italic>\n                    gene, which encodes its receptor, has variants such as T280M and V249I, which are associated with reduced cell adhesion and deficiencies in chemotaxis. These variants have been implicated in various diseases and in reduced immune response against cancer. Although the\n                    <jats:italic toggle=\"yes\">fractalkine<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">CX3CR1<\/jats:italic>\n                    axis may have protective or tumorigenic effects depending on the type of cancer, in OSCC its activation seems to favor tumor invasion and metastasis. Future studies could determine its impact on the development and treatment of this disease.\n                  <\/jats:p>","DOI":"10.1177\/03936155251345080","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:59:26Z","timestamp":1748491166000},"page":"83-86","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunogenetic contribution of the\n                    <i>fractalkine<\/i>\n                    \/\n                    <i>CX3CR1<\/i>\n                    axis in oral squamous cell carcinoma"],"prefix":"10.1177","volume":"40","author":[{"given":"Mario Alberto","family":"Alarc\u00f3n-S\u00e1nchez","sequence":"first","affiliation":[{"name":"University of Guadalajara (CUCS-UdeG)"},{"name":"University of Guadalajara (CUCS-UdeG)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilibeth-Stephania","family":"Escoto-Vasquez","sequence":"additional","affiliation":[{"name":"National Autonomous University of Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta Sarai","family":"Becerra-Ruiz","sequence":"additional","affiliation":[{"name":"University of Guadalajara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Rivera-Solano","sequence":"additional","affiliation":[{"name":"South Pacific Dental Institute, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12746-0"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22941.1"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052634"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/385640a0"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094679"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.23799"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1065213"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0343-6"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17750"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092050"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.2833"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103723"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2024.04.002"}],"container-title":["The International Journal of Biological Markers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03936155251345080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03936155251345080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03936155251345080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:00:50Z","timestamp":1777492850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03936155251345080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/03936155251345080"],"URL":"https:\/\/doi.org\/10.1177\/03936155251345080","relation":{},"ISSN":["0393-6155","1724-6008"],"issn-type":[{"value":"0393-6155","type":"print"},{"value":"1724-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}