{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:20:19Z","timestamp":1787732419782,"version":"build-2784847793"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities","award":["202301BA070001-26;202301BA070001-27"],"award-info":[{"award-number":["202301BA070001-26;202301BA070001-27"]}]},{"name":"Science Research Foundation of Education Department of Yunnan Province","award":["2022J0716"],"award-info":[{"award-number":["2022J0716"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Although human lysine oxidase-like 3 (LOXL3) is associated with various cancers, its role in pleural mesothelioma (PM) remains uncharacterized. This study investigated the expression level and prognostic association of LOXL3 in PM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Tissue specimens were collected from patients with PM. The expression levels of LOXL3 were assessed using immunohistochemistry, Western blot analysis, and quantitative reverse transcription PCR. The clinical correlation analysis was conducted using R software (version 3.6.3), incorporating data from both The Cancer Genome Atlas and Chuxiong cohorts. Univariate and multivariate Cox proportional hazards regression models alongside Kaplan\u2013Meier survival curve analysis were performed to evaluate prognostic significance. Additionally, gene expression correlation studies between LOXL3 and other members of the LOX family were performed using the Gene Expression Profiling Interactive Analysis platform. Finally, Gene Set Enrichment Analysis was conducted to identify the signaling pathways associated with LOXL3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LOXL3 exhibited significant upregulation in both sarcomatoid and biphasic PM subtypes compared to the control samples. Clinico-pathological analysis revealed the correlations between LOXL3 expression levels and cancer type, and Wilms tumor protein 1 (WT-1) status. Cox regression analysis identified cancer type as an independent prognostic factor. Kaplan\u2013Meier analysis demonstrated obviously poorer survival rates in cohorts with high LOXL3 expression. Notably, coordinated expression patterns were observed between LOXL3 and LOXL4. The protein expression level of LOXL3 exhibits a positive correlation with CD68, CD206, and programmed death-ligand 1 (PD-L1), with this correlation being particularly pronounced in sarcomatoid mesothelioma. Functional enrichment analysis indicated that high LOXL3 expression was primarily associated with pathways related to oxidative phosphorylation, late and early estrogen response, and adipogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LOXL3 is highly expressed in PM and associated with poor prognosis, and is involved in tumor immune evasion. The expression level of LOXL3 is correlated with cancer types and the expression level of WT-1. Cancer type is an independent prognostic factor for PM. LOXL3 expression is positively associated with LOXL4, and high LOXL3 expression is enriched in oxidative phosphorylation, estrogen response, and adipogenesis pathways, while the low-expression group is enriched in apoptosis, interleukin-2\/signal transducer and activator of transcription 5, mammalian target of rapamycin complex 1, and transforming growth factor-\u03b2 pathways. CD68, CD206, PD-L1, and LOXL3 may collaboratively contribute to the regulation of the PM microenvironment and are closely linked to the invasion and metastasis of PM. Therefore, LOXL3 can be used as both a prognostic marker and a potential therapeutic target for PM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155251396145","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:44:38Z","timestamp":1764758678000},"page":"254-265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Human lysine oxidase-like 3 high expression as a potential biomarker and association with poor prognosis in pleural mesothelioma"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-0582","authenticated-orcid":false,"given":"Wen","family":"Mei","sequence":"first","affiliation":[{"name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The People's Hospital of Chuxiong Yi Autonomous Prefecture, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunshan","family":"Fu","sequence":"additional","affiliation":[{"name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"He","sequence":"additional","affiliation":[{"name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Sun","sequence":"additional","affiliation":[{"name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical Biochemistry of Yunnan Province, College of Basic Medical Sciences, Dali University, China"},{"name":"Key Laboratory of Entomological Biopharmaceutical Research and Development of Yunnan, College of Pharmacy, Dali University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yepin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The People's Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"Management of malignant pleural mesothelioma-the European experience","author":"Opitz I","year":"2014","unstructured":"Opitz I. 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