{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:17:01Z","timestamp":1783225021348,"version":"3.54.6"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Biol Markers"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric cancer (GC) is a highly prevalent malignant tumor worldwide. Traditional treatment approaches have numerous limitations, and messenger RNA (mRNA)-targeted therapy offers a new direction for the treatment of GC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the expression characteristics and clinical significance of miR-145-3p in GC, as well as its mechanism of action in regulating GC cell function by targeting CREB1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-145-3p and CREB1 in GC tissues, serum, and cell lines. Cell Counting Kit-8, Transwell, and qRT-PCR assays were employed to evaluate the effects of miR-145-3p and CREB1 on GC cell proliferation, migration, invasion, and apoptosis. Bioinformatics prediction, dual-luciferase reporter assays, and rescue experiments were conducted to validate the targeted regulatory relationship between miR-145-3p and CREB1. Downstream signaling pathways were analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>miR-145-3p is significantly downregulated in GC, which is closely linked with tumor malignant progression and negative prognosis. miR-145-3p mimic inhibits the proliferation, migration, and invasion of GC cells while promoting apoptosis; conversely, CREB1 OE produces the opposite effect. Bioinformatics and functional experiments confirmed that miR-145-3p targets CREB1, and CREB1 OE partially reverses the tumor-suppressive effects of miR-145-3p. GO and KEGG analyses revealed that the miR-145-3p\/CREB1 axis participates in transcription regulation, metabolism, and virus-related carcinogenesis pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miR-145-3p exerts effects in GC, at least in part, by targeting and inhibiting CREB1, positioning it as a potential molecular target for GC diagnosis, prognosis assessment, and mRNA-targeted therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03936155261461771","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:53:48Z","timestamp":1783065228000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The diagnostic and predictive value of miR-145-3p in gastric cancer and its regulation of gastric cancer progression via targeting CREB1"],"prefix":"10.1177","volume":"41","author":[{"given":"Kaitao","family":"Yao","sequence":"first","affiliation":[{"name":"Wuhan NO.9 Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jingzhou Hospital of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1771-6600","authenticated-orcid":false,"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huanggang Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01698-y"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i16.2452"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00052-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09925-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5672"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2024.139"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.06.044"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i39.10948"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.10.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-024-02579-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.10.001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/2211536605666160825151201"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2823-2_1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.034"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27486"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151576"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0563-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i11.1206"},{"key":"e_1_3_2_20_2","first-page":"695","article-title":"LINC00958 Targets miR-145-3p\/CDK1 axis to aggravate the malignancy of colon cancer","volume":"52","author":"Zhou L","year":"2022","unstructured":"Zhou L, Mu D, Chen Y. 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