{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:40:50Z","timestamp":1777711250284,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Thymomas are rare tumours that sustain T-lymphopoiesis and trigger a variety of autoimmune diseases and immunodeficiencies, including a fatal hypogammaglobulinemia, namely Good's Syndrome (GS). Due to its rarity, GS has been poorly investigated and immunological features, as well as pathogenetic mechanisms underlying this syndrome, are unclear. We studied 30 thymoma patients by performing an immunological assessment, including immunophenotype and analysis of T cell repertoire (TCR). Development of GS was characterized by a progressive decrease in B, CD4 T and NK lymphocytes. These alterations paired with accumulation of CD8+CD45RA+ T cells that showed a polyclonal repertoire without expansions of specific clonotypes. GS is defined as hypogammaglobulinemia with thymoma. Here, we show for the first time that this syndrome is characterized by a severe loss of CD4+, NK and B cells. Furthermore, the accumulation of CD8+CD45RA+ T lymphocytes parallels these changes; this accumulation may have a role in determining the disease and can be used to monitor clinical stages of immunodeficiency in thymoma.<\/jats:p>","DOI":"10.1177\/039463201002300129","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T14:24:48Z","timestamp":1484058288000},"page":"307-316","source":"Crossref","is-referenced-by-count":16,"title":["Thymoma-Associated Immunodeficiency: A Syndrome Characterized by Severe Alterations in NK, T and B-Cells and Progressive Increase in Na\u00efve CD8+ T Cells"],"prefix":"10.1177","volume":"23","author":[{"given":"L.","family":"Vitiello","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples"},{"name":"Laboratory of Immunobiology of Cardiovascular Diseases, Department of Medical Science and Rehabilitation, IRCCS San Raffaele Pisana, Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Masci","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples"},{"name":"Laboratory of Immunobiology of Cardiovascular Diseases, Department of Medical Science and Rehabilitation, IRCCS San Raffaele Pisana, Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Montella","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Unit, \u201cS Giovanni di Dio\u201d Hospital, Frattaminore, Naples"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Perna","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Medicine Department, Federico II University of Naples"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.F.","family":"Angelini","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Borsellino","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Battistini","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Merola","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples"},{"name":"Department of Molecular and Clinical Oncology and Endocrinology, Federico II University of Naples"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"De Palma","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine, Department of Clinical and Experimental Medicine F. 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