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IL-10 is an anti-inflammatory cytokine that inhibits the production of proinflammatory cytokines and induces HLA-class II down-modulation. Recent studies suggest that HLA-G could play a role in SNP pathogenesis; in SNP patients physiological levels of IL-10 (produced by activated peripheral blood CD14+ monocytes) are not able to induce production of HLA-G. Different mechanisms could justify these findings: genomic or amino-acidic sequence alterations in IL-10 lower IL-10 receptor expression, lower IL-10 receptor affinity, or alterations of the intracellular signal transmission. This study analyzes nucleotidic sequence of IL-10 gene in SNP patients. Sequencing of IL-10 gene shows that the lack of HLA-G production by peripheral blood CD14+ monocytes is not related to alterations in IL-10 gene nucleotidic sequence.<\/jats:p>","DOI":"10.1177\/0394632015573922","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T22:31:33Z","timestamp":1428532293000},"page":"434-439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of Il-10 gene sequence in patients with sinonasal polyposis"],"prefix":"10.1177","volume":"28","author":[{"given":"N","family":"Malagutti","sequence":"first","affiliation":[{"name":"Department of Otolaringology, University of Ferrara, St Anna Hospital, Cona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Stomeo","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, University of Ferrara, St Anna Hospital, Cona, 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