{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:55:46Z","timestamp":1777712146668,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Sweet\u2019s syndrome, or acute febrile neutrophilic dermatosis, is an uncommon severe cutaneous condition, not previously associated with allopurinol therapy. We describe the case of an 87-year-old woman with hyperuricemia who developed classic Sweet\u2019s syndrome manifestations 8 days after being treated with allopurinol. Patient\u2019s symptoms included fever, painful edema in the hands and lower limbs with non-pruritic erythematous plaques topped by pus-filled skin blisters, right eye conjunctivitis, splenomegaly and joint pain. At the emergency department, blood tests showed neutrophilic leukocytosis, inflammatory state and altered liver function. During hospitalization, she received unsuccessful treatments with two different antibiotics (namely ceftriaxone and levofloxacin), while treatment with intravenous methylprednisolone produced a rapid clinical remission of symptoms, cutaneous lesion pain improvement, normalization of her body temperature and her blood values returned to normal. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship between the patient\u2019s development of Sweet\u2019s syndrome and allopurinol therapy. Because the signs and symptoms of Sweet\u2019s syndrome resemble an infectious process, the correct diagnosis may be delayed and inappropriate treatment regimen with antibiotics may often precede glucocorticoid therapy.<\/jats:p>","DOI":"10.1177\/0394632015599705","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T23:56:18Z","timestamp":1450482978000},"page":"329-332","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Allopurinol-induced Sweet\u2019s syndrome"],"prefix":"10.1177","volume":"29","author":[{"given":"G","family":"Polimeni","sequence":"first","affiliation":[{"name":"Sicilian Regional Centre of Pharmacovigilance, Clinical Pharmacology Unit \u2013 AOU Policlinico \u201cG. Martino\u201d, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Cardillo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital S. Marta e S. Venera - ASP CT, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Garaffo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital S. Marta e S. Venera - ASP CT, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Giardina","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Sirna","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Department of Clinical Experimental Medicine, Unit of Dermatology, University of Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Arcoraci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"bibr1-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1964.tb14541.x"},{"key":"bibr2-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H563"},{"key":"bibr3-0394632015599705","first-page":"331","volume":"137","author":"Guarneri C","year":"2002","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"bibr4-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00125-X"},{"key":"bibr5-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70215-2"},{"key":"bibr6-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01891.x"},{"key":"bibr7-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb08668.x"},{"key":"bibr8-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.050"},{"key":"bibr9-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90080-8"},{"key":"bibr10-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.10.2011.4935."},{"key":"bibr11-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00006-2"},{"key":"bibr12-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197911000-00004"},{"key":"bibr13-0394632015599705","unstructured":"Micromedex\u00ae 2.0 ev. Truven Health Analytics, Greenwood Village, Colorado, USA. Available at: http:\/\/www.micromedexsolutions.com (accessed 26 June 2015)."},{"key":"bibr14-0394632015599705","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0394632015599705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0394632015599705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0394632015599705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:04:22Z","timestamp":1777457062000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0394632015599705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1177\/0394632015599705"],"URL":"https:\/\/doi.org\/10.1177\/0394632015599705","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,18]]}}}