{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:06:35Z","timestamp":1791068795296,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>The failure of traditional antimicrobial treatments is becoming a worldwide problem. The use of Aloe vera is of particular interest for its role as curative agent and its efficacy in complementary therapies for a variety of illnesses. This study evaluated the antimicrobial activity of A. vera inner gel against a panel of microorganisms, Gram-positive and -negative bacteria, and Candida albicans. In addition to A. vera inner gel being used in the treatment of peptic ulcers, in dermatological treatments, and wound healing, it was also tested on the sessile phase of clinical Helicobacter pylori strains (including multi-drug-resistant strains) and on planktonic and sessile phase of Staphylococcus aureus\/Pseudomonas aeruginosa clinical isolates from venous leg ulcers.<\/jats:p>\n                  <jats:p>A. vera inner gel expresses its prevalent activity against Gram-negative bacteria and C. albicans in respect to Gram-positive bacteria. The results of the A. vera antibiofilm activity showed a decrease of the produced biomass in a concentration-dependent-way, in each analyzed microorganism. The data obtained show that A. vera inner gel has both an antimicrobial and antibiofilm activity suggesting its potential use for the treatment of microbial infections, in particular for H. pylori gastric infection, especially in case of multi-drug-resistance, as well as for an effective wound dressing.<\/jats:p>","DOI":"10.1177\/0394632015600594","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T06:57:27Z","timestamp":1446447447000},"page":"595-602","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["<i>In vitro<\/i>\n                    activity of\n                    <i>Aloe vera<\/i>\n                    inner gel against microorganisms grown in planktonic and sessile phases"],"prefix":"10.1177","volume":"28","author":[{"given":"V","family":"Cataldi","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Di Bartolomeo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Di Campli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nostro","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Health Products, University of Messina, Polo Annunziata, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cellini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"bibr1-0394632015600594","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00910.x"},{"key":"bibr2-0394632015600594","doi-asserted-by":"publisher","DOI":"10.1007\/s10541-005-0111-6"},{"key":"bibr3-0394632015600594","first-page":"71","volume":"2","author":"Taylor PW","year":"2005","journal-title":"Food Science and Technology Bulletin"},{"key":"bibr4-0394632015600594","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-009-8577-0"},{"key":"bibr5-0394632015600594","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2014.10.006"},{"key":"bibr6-0394632015600594","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13081599"},{"key":"bibr7-0394632015600594","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.54.15"},{"key":"bibr8-0394632015600594","first-page":"823","volume":"49","author":"Vogler BK","year":"1999","journal-title":"British Journal of General Practice"},{"key":"bibr9-0394632015600594","doi-asserted-by":"publisher","DOI":"10.4066\/AMJ.2012.1301"},{"key":"bibr10-0394632015600594","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12241"},{"key":"bibr11-0394632015600594","first-page":"1","volume":"10","author":"Bessa LJ","year":"2013","journal-title":"International Wound Journal"},{"key":"bibr12-0394632015600594","first-page":"467","volume":"23","author":"Marzio L","year":"2011","journal-title":"European Journal of Gastroenterology & Hepatology"},{"key":"bibr13-0394632015600594","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00321.x"},{"key":"bibr14-0394632015600594","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria; 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