{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:56:00Z","timestamp":1777712160903,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>The role of endothelium in the progression of atheromasic disease has already been demonstrated. Endothelin-1 (ET-1) is released from endothelial cells during acute and chronic vascular damage and it appears to be the strongest vasoconstrictor agent known.<\/jats:p>\n                  <jats:p>The aim of this study is to investigate the amount of endothelial damage in patients with unstable angina (UA), as defined by serum levels of ET-1, to verify a possible correlation with increased ischaemic damage by evaluation of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and interleukin 8 (IL-8) levels.<\/jats:p>\n                  <jats:p>Serum levels of ET-1, IL-8 and NT-proBNP obtained from 10 patients affected by low-risk UA were compared to those belonging to eight healthy subjects. In order to compare the laboratory data pertaining to the two populations, a Student\u2019s t-test and a Mann-Whitney U test were performed.<\/jats:p>\n                  <jats:p>Levels of ET-1, IL-8 and NT-proBNP in samples of peripheral blood of patients affected by UA were significantly elevated, compared with those of the control group. The linear correlation analysis demonstrated a positive and significant correlation between levels of ET-1 and IL-8, between levels of ET-1 and NT-proBNP, and between levels of IL-8 and NT-proBNP in subjects affected by UA.<\/jats:p>\n                  <jats:p>Early elevated levels of ET-1, IL-8 and NT-proBNP in patients with UA show a coexistence between ischaemic insults and endothelial damages. A positive and significant linear correlation between levels of ET-1 and IL-8, between levels of ET-1 and NT-proBNP, and between levels of IL-8 and NT-proBNP confirms that an increased ischaemic insult is correlated to inflammation signs and endothelium damage signs.<\/jats:p>\n                  <jats:p>In patients with UA, ischaemia is always associated with a systemic immuno-mediated activity induced by acute endothelial damage. We suggest early administration of ET-1-selective receptor blockers and anti-inflammatory drugs.<\/jats:p>","DOI":"10.1177\/0394632015608247","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T23:56:18Z","timestamp":1450482978000},"page":"516-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Endothelial immunomediated reactivity in acute cardiac ischaemia: Role of endothelin 1, interleukin 8 and NT-proBNP in patients affected by unstable angina pectoris"],"prefix":"10.1177","volume":"29","author":[{"given":"Costantino","family":"Caroselli","sequence":"first","affiliation":[{"name":"U.O.C. Pronto Soccorso, Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.) Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"De Rosa","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia 3, Dipartimento di Cardioscienze, Azienda Ospedaliera S. Camillo- Forlanini, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Tanzi","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia 3, Dipartimento di Cardioscienze, Azienda Ospedaliera S. Camillo- Forlanini, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Rigatelli","sequence":"additional","affiliation":[{"name":"U.O.C. Pronto Soccorso, Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.) Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Bruno","sequence":"additional","affiliation":[{"name":"U.O.C. Medicina Interna, Policlinico Sant\u2019Andrea, Facolt\u00e0 di Medicina e Psicologia \u2013 \u201cSapienza\u201d, Universit\u00e0 di Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"bibr1-0394632015608247","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv029"},{"key":"bibr2-0394632015608247","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.039"},{"key":"bibr3-0394632015608247","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.316"},{"key":"bibr4-0394632015608247","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12406"},{"key":"bibr5-0394632015608247","first-page":"324","volume":"65","author":"Joffre J","year":"2015","journal-title":"La Revue du Praticien"},{"key":"bibr6-0394632015608247","first-page":"441","volume":"92","author":"Tousoulis 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