{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:55:52Z","timestamp":1777712152522,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    The purpose of this investigation was to determine the lymphocyte subset response to 30 min of moderate treadmill exercise during caffeine supplemented (6.0 mg.kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and placebo conditions in caffeine-na\u00efve and -familiar individuals. Seventeen individuals participated (caffeine-familiar = 8, caffeine-na\u00efve = 9) completing two exercise bouts (caffeine supplemented and placebo control) 48 h apart in a counterbalanced and double-blinded fashion. Individuals were classified as follows: caffeine-naive &lt;50 mg.d\n                    <jats:sup>\u22121<\/jats:sup>\n                    and caffeine-familiar &gt;200 mg.d\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Whole blood samples were obtained at rest, 30 min after caffeine or placebo ingestion, immediately following exercise, and 1 h post exercise. Blood was used to analyze apoptosis (annexin V) and cellular migration (CX\n                    <jats:sub>3<\/jats:sub>\n                    CR1) responses in lymphocyte subsets (CD4+, CD8+, CD19+). Absolute changes from rest values were calculated and differences between conditions were determined through Chi-squared analysis with significance accepted at P &lt;0.05. With regard to CD4+ and CD19+ lymphocytes, the interaction of caffeine and exercise did not affect na\u00efve individuals to a greater extent immediately post exercise when compared to familiar, as similar apoptotic and migratory responses were observed ( P &gt;0.05). However, CD8+ lymphocyte cell death and migration responses were observed to be significantly greater at each sampling point in caffeine-familiar individuals ( P &lt;0.05). It is possible that chronic caffeine supplementation may prime CD8+ cell receptors for responsiveness to apoptosis and migration and the consequence of this form of immunosuppression in the post-exercise period should be determined.\n                  <\/jats:p>","DOI":"10.1177\/0394632015612795","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T23:56:18Z","timestamp":1450482978000},"page":"288-294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Caffeine affects CD8+ lymphocyte apoptosis and migration differently in na\u00efve and familiar individuals following moderate intensity exercise"],"prefix":"10.1177","volume":"29","author":[{"given":"James W","family":"Navalta","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Fedor","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Schafer","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T Scott","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramires A","family":"Tibana","sequence":"additional","affiliation":[{"name":"Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme B","family":"Pereira","sequence":"additional","affiliation":[{"name":"Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonato","family":"Prestes","sequence":"additional","affiliation":[{"name":"Graduate Program on Physical Education, Catholic University of Brasilia, Brasilia, 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