{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:55:53Z","timestamp":1777712153430,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>The chief manifestations of scabies are mediated through hypersensitivity-like reactions and immune responses which are so far not well understood and remain poorly characterized. The aim of this study is to investigate the role of inflammatory cytokines in relation to humoral immunity in patients with scabies. Serum levels of total IgE, specific IgG, IL-10, IL-6, INF-\u03b3, and TNF-\u03b1 were investigated in a cross-sectional study including 37 patients with manifestations suggestive of scabies and serologically positive for anti- Sarcoptes IgG, in addition to 20 healthy controls. The median value of total IgE was 209 (range, 17\u20131219 IU\/mL), reflecting its wide range within cases. IL-10 showed significant higher levels (287 \u00b1 139) in cases than in controls (17.4 \u00b1 11.32). A positive correlation was reported between total IgE and severity of manifestations (r = 0.429, P &lt;0.005). A significant positive correlation was observed between total IgE and both IgG and IL-6. On the contrary, a negative correlation was recorded between IL-6 and TNF-\u03b1 which makes us suggested anti-inflammatory rather than pro-inflammatory effect of IL-6. Moreover, a negative correlation was noticed between the anti-inflammatory cytokine IL-10 and severity of manifestations, specific IgG, total IgE, and INF-\u03b3. Therefore, the current study theorized a regulatory role of IL-10 in inflammatory responses of scabietic patients suggesting further future analysis of its therapeutic potential.<\/jats:p>","DOI":"10.1177\/0394632015627464","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T20:17:49Z","timestamp":1453839469000},"page":"188-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies"],"prefix":"10.1177","volume":"29","author":[{"given":"Amany Ahmed","family":"Abd El-Aal","sequence":"first","affiliation":[{"name":"Parasitology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa Adel","family":"Hassan","sequence":"additional","affiliation":[{"name":"Parasitology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba Ismail","family":"Gawdat","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meran Ahmed","family":"Ali","sequence":"additional","affiliation":[{"name":"Parasitology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal","family":"Barakat","sequence":"additional","affiliation":[{"name":"Clinical pathology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"bibr1-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4211.405"},{"key":"bibr2-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00042-06"},{"key":"bibr3-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.125"},{"key":"bibr4-0394632015627464","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-3024.2010.01218.x","volume":"32","author":"Walton SF","year":"2010","journal-title":"Parasite Immunology"},{"key":"bibr5-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000756"},{"key":"bibr6-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01809.x"},{"key":"bibr7-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp052784"},{"key":"bibr8-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1975.tb01832.x"},{"key":"bibr9-0394632015627464","first-page":"l5","volume":"68","author":"Barbee RA","year":"1981","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"bibr10-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb05672.x"},{"key":"bibr11-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1984.tb00758.x"},{"key":"bibr12-0394632015627464","first-page":"37","volume":"4","author":"Senol M","year":"1997","journal-title":"Journal of Turgut Ozal Medical Centre"},{"key":"bibr13-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08541.x"},{"key":"bibr14-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1981.tb00844.x"},{"key":"bibr15-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1159\/000249715"},{"key":"bibr16-0394632015627464","first-page":"221","volume":"23","author":"Morsy TA","year":"1993","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"bibr17-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12680433"},{"key":"bibr18-0394632015627464","first-page":"765","volume":"21","author":"Nassef NE","year":"1991","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"bibr19-0394632015627464","first-page":"565","volume":"20","author":"Morsy TA","year":"1990","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"bibr20-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1992.tb01353.x"},{"key":"bibr21-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00195-10"},{"key":"bibr22-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62599-9"},{"key":"bibr23-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.8.2654"},{"key":"bibr24-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00839.x"},{"key":"bibr25-0394632015627464","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.08.033"},{"key":"bibr26-0394632015627464","unstructured":"Kennedy SB (2007) Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo. 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