{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:32:02Z","timestamp":1785439922523,"version":"3.56.0"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Western Regional Health Authority of Norway"},{"DOI":"10.13039\/501100007872","name":"Grieg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005036","name":"Universitetet i Bergen","doi-asserted-by":"publisher","award":["Hjertefondet"],"award-info":[{"award-number":["Hjertefondet"]}],"id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Objective: Psoriasis is an immune mediated disorder associated with T cell activation and cardiovascular disease (CVD). We explored the association of inflammation with left ventricular (LV) remodelling in psoriasis patients receiving treatment with the tumour necrosis factor-\u03b1 (TNF-\u03b1) blocker infliximab. Methods: Psoriasis patients ( n = 47, age 47 \u00b1 14 years, 66% men) and 99 control subjects without psoriasis (age 47 \u00b1 11 years, 72% men) were examined by echocardiography in a cross-sectional study. LV remodelling was assessed by LV mass index for height in the allometric power of 2.7. Serum concentrations of C-reactive protein (CRP), serum amyloid A (SAA), neopterin, kynurenine:tryptophan ratio (KTR) and the pyridoxic acid ratio (PAr) index were measured. Results: Serum concentration of neopterin ( p = .007) was higher in psoriasis patients, while the other inflammatory biomarkers had similar levels. LV mass index was lower in patients than controls (35.6 \u00b1 9.6\u00a0g\/m\n                    <jats:sup>2.7<\/jats:sup>\n                    vs. 40.3 \u00b1 9.8\u00a0g\/m\n                    <jats:sup>2.7<\/jats:sup>\n                    , p = .008). In the total study population, serum SAA (\u03b2 = 0.18, p = .02), KTR (\u03b2 = 0.20, p = .02) and the PAr index (\u03b2 = 0.26, p = .002) were all associated with higher LV mass index independent of age, sex, body mass index, hypertension, smoking, renal function and psoriasis. Also in psoriasis patients, higher SAA level (\u03b2 = 0.34, p = .02), KTR (\u03b2 = 0.32, p = .02) and the PAr index (\u03b2 = 0.29, p = .05) were associated with higher LV mass index independent of body mass index, hypertension and diabetes. Conclusion: Higher levels of the inflammatory biomarkers SAA, KTR and the PAr index were associated with greater LV mass index in psoriasis patients, indicating a role of chronic inflammation in LV remodelling evident even during treatment with TNF-\u03b1 blockers.\n                  <\/jats:p>","DOI":"10.1177\/03946320221111131","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T10:17:44Z","timestamp":1660385864000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomarkers of inflammation and left ventricular remodelling in psoriasis patients treated with infliximab"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-9914","authenticated-orcid":false,"given":"Helga","family":"Midtb\u00f8","sequence":"first","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Bergen, Norway"},{"name":"Centre for 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Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Meyer","sequence":"additional","affiliation":[{"name":"Bevital AS, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Linde","sequence":"additional","affiliation":[{"name":"Centre for Research on Cardiac Disease in Women, Department of Clinical Science, University of Bergen, Bergen, Norway"},{"name":"Norwegian Research Centre for Women\u2019s Health, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arve","family":"Ulvik","sequence":"additional","affiliation":[{"name":"Bevital AS, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re Steinar","family":"Tveit","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Haukeland University Hospital, Bergen, 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