{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:04:38Z","timestamp":1780405478252,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Introduction: Progesterone is essential for both the initiation and the maintenance of pregnancy. The immunological effects of progesterone are mediated by the progesterone-induced blocking factor (PIBF), which is an immunomodulatory factor with anti-abortive properties. The aim of the research was to establish the cytokine profile and PIBF1 concentration in follicular fluid (FF) of patients undergoing in vitro fertilization (IVF).<\/jats:p>\n                  <jats:p>Methods: Seventy-eight patients who qualified for IVF underwent a detailed medical interview, including the course of fertility treatment and physical, gynecological, and cytological examinations. The concentration of PIBF1, IL-18, IL-2, IL-4, IL-6, IL-10, interferon-\u03b3 (IFN-\u03b3), IL-1\u03b1, IL-1\u03b2, IL-5, IL-8, and IL-15 in FF during ovarian puncture was measured using commercially available ELISA kits.<\/jats:p>\n                  <jats:p>Results: IL-1 beta concentration was lower in the FF of patients with successful IVF. IL-8 concentration in FF correlated with the number of cumulus-oocyte complexes (COC-1), metaphase II (MII), and top-quality embryos. PIBF1 concentration had a positive correlation with the number of MII and top-quality embryos. IL-2 and IL-6 concentrations were positively correlated with the number of COC-1 and MII. An important parameter in assessing the chances of successful IVF is the number of top-quality embryos achieved.<\/jats:p>\n                  <jats:p>Conclusion: Higher PIBF1 concentration in FF may indicate a greater possibility of successful IVF due to the higher number of top-quality embryos. IL-1 beta concentration was found to be lower in the FF of patients with successful IVF. Therefore, PIBF1 and IL-1 beta in FF could be candidates for a marker of successful IVF.<\/jats:p>","DOI":"10.1177\/03946320221111134","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T06:36:02Z","timestamp":1658385362000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Progesterone-induced blocking factor 1 and cytokine profile of follicular fluid of infertile women qualified to in vitro fertilization: The influence on fetus development and pregnancy outcome"],"prefix":"10.1177","volume":"36","author":[{"given":"Rafa\u0142","family":"Adamczak","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-8382","authenticated-orcid":false,"given":"Natalia","family":"Ukleja-Soko\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Lis","sequence":"additional","affiliation":[{"name":"Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Bartuzi","sequence":"additional","affiliation":[{"name":"Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Dubiel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"bibr1-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.06.002"},{"key":"bibr2-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103150"},{"key":"bibr3-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1007\/s12177-009-9026-6"},{"key":"bibr4-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01972-3"},{"key":"bibr5-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1404-3"},{"key":"bibr6-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108858"},{"key":"bibr7-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20326"},{"key":"bibr8-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.206.151"},{"key":"bibr9-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1177\/20587384211066718"},{"issue":"2","key":"bibr10-03946320221111134","first-page":"149","volume":"83","author":"Kuczy\u0144ski W","year":"2012","journal-title":"Ginekol Pol"},{"key":"bibr11-03946320221111134","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoz025"},{"key":"bibr12-03946320221111134","unstructured":"Gardner DK, Schoolcraft WB, Jansen R, et al. 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