{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:44:36Z","timestamp":1790775876622,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Hormesis or low-dose ionizing radiation is known to induce various biological responses, a subcategory of which is the adaptive response, which has been reported to protect against higher radiation doses via multiple mechanisms. This study investigated the role of the cell-mediated immunological component of low-dose ionizing radiation-induced adaptive response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Herein, male albino rats were exposed to whole-body gamma radiation, using a Cs\n                      <jats:sup>137<\/jats:sup>\n                      source with low-dose ionizing radiation doses of 0.25 and 0.5\u00a0Gray (Gy); 14 days later, another irradiation session at a dose level of 5\u00a0Gy was carried on. Four days post-irradiation at 5\u00a0Gy, rats were sacrificed. The low-dose ionizing radiation-induced immuno-radiological response has been assessed through the T-cell receptor (TCR) gene expression quantification. Also, the serum levels of each of interleukins-2 and -10 (IL-2, IL-10), transforming growth factor-beta (TGF-\u03b2), and 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) were quantified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Results indicated that priming low irradiation doses resulted in significant decrements in TCR gene expression and the serum levels of IL-2, TGF-\u03b2, and 8-OHdG with an increment in IL-10 expression compared to the irradiated group, which did not receive low priming doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The observed low-dose ionizing radiation-induced radio-adaptive response significantly protected against high irradiation dose injuries, through immune suppression, representing a promising pre-clinical protocol that would be applied to minimize radiotherapy side effects on normal but not against the tumor cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320231172080","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T17:15:09Z","timestamp":1681924509000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Immune system modulation by low-dose ionizing radiation-induced adaptive response"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-6400","authenticated-orcid":false,"given":"Soha M","family":"Hussien","sequence":"first","affiliation":[{"name":"Department of Radiation Safety, Nuclear and Radiological Safety Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-378X","authenticated-orcid":false,"given":"Engy R","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Drug Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"bibr1-03946320231172080","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.02.007"},{"key":"bibr2-03946320231172080","author":"Sologuren I","year":"2014","journal-title":"Transl Cancer Res Vol 3, No 1 (February 2014) Transl Cancer Res (Intraoperative Radiother I)"},{"key":"bibr3-03946320231172080","doi-asserted-by":"crossref","unstructured":"Lau YS, Chew MT, Alqahtani A, Jones B, Hill MA, Nisbet A, Bradley DA (2021) Low Dose Ionising Radiation-Induced Hormesis: Therapeutic Implications to Human Health. 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