{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:00:40Z","timestamp":1792620040492,"version":"4.5.0"},"reference-count":67,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Testicular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine\u2019s possible mechanisms and protective effects against testicular damage using a rat model of streptozotocin-induced diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wistar rats ( N = 56) were divided into seven equal groups. Untreated control rats received saline, and treated control rats received taurine 50\u00a0mg\/kg orally. To induce diabetes, rats received a single dose of streptozotocin. Metformin-treated diabetic rats received metformin at a dose of 300\u00a0mg\/kg. Taurine-treated groups received 10, 25, or 50\u00a0mg\/kg. All treatments were provided orally once a day for 9\u00a0weeks following the streptozotocin injection. Levels of blood glucose, serum insulin, cholesterol, testicular tumour necrosis factor-alpha (TNF-\u03b1), interleukin-6 (IL-6), interleukin-1beta (IL-1\u03b2), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), and catalase (CAT) were examined. Sperm count, progressive sperm motility, and sperm abnormalities were examined. Body and relative reproductive gland weights were assessed. Histopathological examinations of the testes and epididymis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Metformin as well as taurine (in a dose-dependent manner) resulted in significant improvements in body and relative reproductive gland weights, blood glucose, serum cholesterol, and insulin levels, as well as cytokine and oxidative parameters. These findings were associated with significant improvement in sperm count, progressive sperm motility, sperm abnormalities, and histopathological lesions in the testes and epididymis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taurine can potentially improve hyperglycemia, hypercholesterolemia, and testicular damage associated with diabetes mellitus, possibly by controlling inflammation and oxidative stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320231172745","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:32:16Z","timestamp":1682519536000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Dose-dependent effects of taurine against testicular damage in a streptozotocin-induced type 1 diabetes mellitus rat model"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-4145","authenticated-orcid":false,"given":"Ahmed H","family":"ElBanna","sequence":"first","affiliation":[{"name":"Michael Sayegh Faculty of Pharmacy, Aqaba University of Technology, Aqaba, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-1724","authenticated-orcid":false,"given":"Afaf S.","family":"Osman","sequence":"additional","affiliation":[{"name":"Medical Pharmacology Department, Faculty of Medicine, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Hossny","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, MSA University, October City, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-7775","authenticated-orcid":false,"given":"Hossny","family":"ElBanna","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-9432","authenticated-orcid":false,"given":"Fatma I.","family":"Abo El-Ela","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"bibr1-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-8422(03)00082-X"},{"key":"bibr2-03946320231172745","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i6.850"},{"key":"bibr3-03946320231172745","doi-asserted-by":"publisher","DOI":"10.5897\/JPAP2013.0001"},{"key":"bibr4-03946320231172745","first-page":"371","volume":"9","author":"Basmatzou T","year":"2016","journal-title":"Int J Caring Sci"},{"key":"bibr5-03946320231172745","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00268"},{"key":"bibr6-03946320231172745","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/686137"},{"key":"bibr7-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.006"},{"key":"bibr8-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114533729"},{"key":"bibr9-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601955"},{"key":"bibr10-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.12.012"},{"key":"bibr11-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.01.008"},{"key":"bibr12-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-008-0258-4"},{"key":"bibr13-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.09.015"},{"key":"bibr14-03946320231172745","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2017.71.380-384"},{"key":"bibr15-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.03.010"},{"key":"bibr16-03946320231172745","doi-asserted-by":"publisher","DOI":"10.4297\/najms.2011.3277"},{"key":"bibr17-03946320231172745","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR2015.5730"},{"key":"bibr18-03946320231172745","unstructured":"Bearden H, Fuquay J (1980) Applied Animal Reproduction. Reston: Reston publishing Co. Inc, 157\u2013165."},{"key":"bibr19-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2017.06.002"},{"issue":"1","key":"bibr20-03946320231172745","first-page":"211","volume":"7","author":"Tatli-\u00c7ankaya I","year":"2014","journal-title":"Asian J Pharmaceut Clin Res"},{"key":"bibr21-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1278453"},{"key":"bibr22-03946320231172745","volume-title":"Theory and Practice of Histological Techniques","author":"Bancroft JDGM","year":"2008"},{"key":"bibr23-03946320231172745","unstructured":"Snedecor G, Cochran W (1982) Statistical Methods. 7th Ed. Ames, USA: The IOWA State Univ Press, pp. 53\u201357."},{"key":"bibr24-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2002.0979"},{"key":"bibr25-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2008.09.006"},{"key":"bibr26-03946320231172745","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8490.65506"},{"key":"bibr27-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-33504-9_14"},{"key":"bibr28-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.05.008"},{"key":"bibr29-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00355.2002"},{"key":"bibr30-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-003-0757-1"},{"key":"bibr31-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-2-46"},{"key":"bibr32-03946320231172745","first-page":"288","volume":"90","author":"Wu N","year":"2010","journal-title":"J Diabetes Res"},{"key":"bibr33-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00168.2004"},{"key":"bibr34-03946320231172745","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23915"},{"key":"bibr35-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.04.030"},{"key":"bibr36-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6130-2_29"},{"key":"bibr37-03946320231172745","unstructured":"\u015eAH\u0130N D Diabetes Mellitus\u2019 un Alzheimer \u0130le Olas\u0131 \u0130li\u015fkisi. T\u0131p Fak\u00fcltesi Klinikleri Dergisi 1: 1\u201312."},{"key":"bibr38-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-024-1079-2_28"},{"key":"bibr39-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1535-z"},{"key":"bibr40-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1763-6"},{"key":"bibr41-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12291"},{"key":"bibr42-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-010-8635-z"},{"key":"bibr43-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.01.018"},{"key":"bibr44-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913080"},{"key":"bibr45-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0919-x"},{"key":"bibr46-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2001.03527.x"},{"key":"bibr47-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.10.4.597"},{"key":"bibr48-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-018-2553-3"},{"key":"bibr49-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.12.014"},{"key":"bibr50-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-46838-7_59"},{"key":"bibr51-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6604"},{"key":"bibr52-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1301"},{"key":"bibr53-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.03.026"},{"key":"bibr54-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.41.2172"},{"key":"bibr55-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2008.00208.x"},{"key":"bibr56-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6093-0_11"},{"key":"bibr57-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01168.x"},{"key":"bibr58-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0366"},{"key":"bibr59-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2017.04.006"},{"key":"bibr60-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26370"},{"key":"bibr61-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/s002400000134"},{"key":"bibr62-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1186\/s41936-018-0070-2"},{"key":"bibr63-03946320231172745","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1308-20"},{"key":"bibr64-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.07.004"},{"key":"bibr65-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.11.055"},{"key":"bibr66-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-024-1079-2_62"},{"key":"bibr67-03946320231172745","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0503"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320231172745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03946320231172745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320231172745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:00:32Z","timestamp":1777456832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03946320231172745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":67,"alternative-id":["10.1177\/03946320231172745"],"URL":"https:\/\/doi.org\/10.1177\/03946320231172745","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"03946320231172745"}}