{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:03:41Z","timestamp":1784207021904,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Different monoclonal antibodies have been used for the treatment of Netherton\u2019s syndrome (NS); secukinumab (anti-IL17A), infliximab (anti-TNF-\u03b1), ustekinumab (anti p40 subunit of IL-12 and IL-23), omalizumab (anti-IgE), and dupilumab (anti-IL4 and IL13). We report two sisters with severe NS who were treated with omalizumab in one and with secukinumab in the other. In view of the therapeutic failure, treatment with dupilumab was started in both sisters. The data were analyzed 16\u00a0weeks after starting treatment with dupilumab. Treatment response was assessed using the Severity Scoring Atopic Dermatitis (SCORAD); Eczema Area and Severity Index (EASI); Pruritus Numeric Rating Scale (NSR); Netherton Area Severity Assessment (NASA) and Dermatology Life Quality Index Ichthyosis. All scores were reduced after 16\u00a0weeks of treatment with dupilumab in both patients. She maintains improvement after 18\u00a0months and 12\u00a0months of treatment, respectively. No severe adverse events were reported. Treatment with dupilumab in two sisters with NS and atopic diseases produced a marked cutaneous improvement after a failed attempt with omalizumab and secukinumab. Further studies are needed to determine which biologic therapy is the most effective in NS.<\/jats:p>","DOI":"10.1177\/03946320231172881","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:29:16Z","timestamp":1684420156000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Report of two sisters with Netherton syndrome successfully treated with dupilumab and review of the literature"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3458-3593","authenticated-orcid":false,"given":"Cristina","family":"Martin-Garc\u00eda","sequence":"first","affiliation":[{"name":"Allergy Service, Hospital Universitario de Salamanca, Spain"},{"name":"Departamento de Ciencias Biom\u00e9dicas y del Diagn\u00f3stico, Facultad de Medicina, Universidad de Salamanca, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBSAL), Salamanca, 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