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Methods: Patients with asthma older than 65\u00a0years old who completed a bronchial provocation test (BPT) or bronchial dilation test (BDT) and a fractional exhaled nitric oxide (FeNO) test between December 2015 and June 2020 were identified retrospectively for this study. All of the patients were categorized into overweight\/obesity and non-obesity groups based on their BMI. Pulmonary function test (PFT) and FeNO measurements were accomplished according to the 2014 recommendations of the Chinese National Guidelines of Pulmonary Function Test and American Thoracic Society\/European Respiratory Society recommendations, respectively. Results: A total of 136 patients with an average age of 71.2 \u00b1 5.40\u00a0years were identified. The average BMI was 23.8 \u00b1 3.63, while the value of FeNO was 42.3 \u00b1 38.4 parts per billion (ppb). In contrast to the non-obesity group, which had a value of 48.8 \u00b1 43.1 ppb for FeNO, the overweight\/obesity group had a significant lower value of 35.4 \u00b1 31.4 ppb. There was no significant difference in the proportion of individuals with high airway hyperresponsiveness between the overweight\/obesity and non-obesity groups (96 patients in total). Multiple linear regression analysis established an inverse correlation between FeNO and Provocation concentration causing a 20% fall in FEV\n                    <jats:sub>1<\/jats:sub>\n                    (PC20) but excluded significant relationships with age and BMI. The model\u2019s R is 0.289, and its p value is 0.045. Conclusion: The elderly Chinese Han asthmatics with overweight\/obesity had lower FeNO levels than those with non-obese according to our findings. In addition, the FeNO level was inversely correlated between FeNO levels and PC20 in elderly asthmatics.\n                  <\/jats:p>","DOI":"10.1177\/03946320241246713","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T19:32:30Z","timestamp":1713814350000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of overweight\/obesity on relationship between fractional exhaled nitric oxide and airway hyperresponsiveness in Chinese elderly patients with asthma"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6981-0269","authenticated-orcid":false,"given":"Fengjia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Departments of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"bibr1-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31147-X"},{"key":"bibr2-03946320241246713","first-page":"2970","volume":"100","author":"Academic Working Committee of Respiratory Branch of Chinese Geriatric Society for Elderly Patients","year":"2020","journal-title":"Chinese Medical Journal"},{"key":"bibr3-03946320241246713","doi-asserted-by":"publisher","DOI":"10.5578\/tt.68041"},{"key":"bibr4-03946320241246713","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S293081"},{"key":"bibr5-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2017.06.005"},{"key":"bibr6-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.004"},{"key":"bibr7-03946320241246713","volume-title":"Global Strategy for Asthma Management and Prevention","author":"Global Initiative for Asthma","year":"2023"},{"key":"bibr8-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1717OC"},{"key":"bibr9-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.05.014"},{"key":"bibr10-03946320241246713","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13030328"},{"key":"bibr11-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00331.2022"},{"key":"bibr12-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31373-6"},{"key":"bibr13-03946320241246713","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-RAI-0461"},{"key":"bibr14-03946320241246713","first-page":"1","volume":"17","author":"Chen C","year":"2004","journal-title":"Biomed Environ Sci"},{"key":"bibr15-03946320241246713","first-page":"566","volume":"37","author":"Pulmonary function Branch of the Chinese Medical Association","year":"2014","journal-title":"Chin J Tuberc Respir Dis"},{"key":"bibr16-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"bibr17-03946320241246713","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.6.423"},{"key":"bibr18-03946320241246713","volume-title":"Jamovi. 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