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This gene expression profiling study was conducted with a preclinical experimental design using a mouse model to examine the molecular-biological characteristics and the pathological implication of total RNA gene interaction in Parkinson\u2019s disease in silico. In silico analysis of total RNA molecules, the Gene Expression Omnibus database, published results, and preliminary findings of available patient samples apply. The potential signaling network and the effect of the interaction of molecules with total RNA was predicted and confirmed. The research consists of four parts. At first, we analyzed the control and MPTP groups. In the second part, we analyzed FVB-N control and MPTP. In the third part, we analyzed controls. In the fourth part, we analyzed MTPT separately. The constructed network contains total RNA, where the Kyoto Encyclopedia of Genes and Genomes database analysis showed that genes from the signaling pathway are involved in the development and complications of Parkinson\u2019s disease in male and female rats. Identified total RNA and genes are involved in altered signaling. There is direct interconnection and interdependence of interactions in the signaling network. Results identified the significant total-RNA molecules of the signaling pathway that connect other molecules. In silico analysis shows upregulated and downregulated genes in Parkinson\u2019s disease rats. Preliminary data shows that total RNA molecules interact with other genes, and they are applicable in Parkinson\u2019s disease course monitoring, shedding light on how factors impact the expression of genes and offering strategies for management.<\/jats:p>","DOI":"10.1177\/03946320241297738","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:05:42Z","timestamp":1737093942000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of total RNA as a potential biomarker of Parkinson\u2019s disease in silico"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-0620","authenticated-orcid":false,"given":"Sne\u017eana M","family":"Jovi\u010di\u0107","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"issue":"23","key":"bibr1-03946320241297738","first-page":"1","volume":"17","author":"Wareham LK","year":"2022","journal-title":"Mol Neurodegener"},{"key":"bibr2-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12852"},{"key":"bibr3-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12433"},{"key":"bibr4-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.615461"},{"key":"bibr5-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.636506"},{"issue":"50","key":"bibr6-03946320241297738","first-page":"1","volume":"17","author":"Lang M","year":"2022","journal-title":"Mol Neurodegener"},{"key":"bibr7-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00775-x"},{"issue":"241","key":"bibr8-03946320241297738","first-page":"2162","volume":"4","author":"Takahashi M","year":"2015","journal-title":"Mol Ther Nucleic Acids"},{"key":"bibr9-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1905057117"},{"key":"bibr10-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.03.003"},{"key":"bibr11-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00265-9"},{"issue":"27","key":"bibr12-03946320241297738","first-page":"11","volume":"7","author":"Romano S","year":"2021","journal-title":"Npj Parkinsons Dis"},{"key":"bibr13-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02656-2"},{"key":"bibr14-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092834"},{"key":"bibr15-03946320241297738","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180308161642"},{"key":"bibr16-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1515\/jib-2021-0027"},{"key":"bibr17-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216246"},{"key":"bibr18-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010712"},{"key":"bibr19-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00566-8"},{"key":"bibr20-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.021"},{"key":"bibr21-03946320241297738","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X1606180608103840"},{"key":"bibr22-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3390\/su142113977"},{"key":"bibr23-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-00981-0"},{"key":"bibr24-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1007\/s11634-021-00455-6"},{"key":"bibr25-03946320241297738","doi-asserted-by":"publisher","DOI":"10.3390\/genes14020419"},{"key":"bibr26-03946320241297738","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-04948-9"},{"key":"bibr27-03946320241297738","unstructured":"European Commission. 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