{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:42:26Z","timestamp":1777711346243,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic dermatosis characterized by recurrent, painful ulcers that commonly affect the lower extremities but can also involve other parts of the body. Over half of patients with PG have concomitant systemic immune diseases, with the association of PG with systemic sclerosis (SSc) being extremely rare. Treatment of PG primarily involves local therapy, steroids, and immunosuppressants, with an increasing emphasis on biologic agents. Among these, tumor necrosis factor-alpha (TNF-\u03b1) antagonists are considered effective. The patient in this report was an elderly female with a history of systemic sclerosis for many years and initially presented with gangrenous ulcers on the fingertips. After inconclusive conventional treatment, adalimumab was added for 5\u2009weeks, resulting in disease suppression, a reduction in ulcer size, and re-epithelialization of the skin lesions after 6\u2009months.<\/jats:p>","DOI":"10.1177\/03946320241300137","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T06:52:47Z","timestamp":1732517567000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of systemic sclerosis complicated with pyoderma gangrenosum with adalimumab: A case report of a rare disease"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1110-9166","authenticated-orcid":false,"given":"Chengqiang","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Qingdao Hiser Hospital Affiliated with Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, Shandong Province, 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