{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:00:27Z","timestamp":1791460827303,"version":"4.3.4"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Our study intended to explore Hesp antioxidant and anti-inflammatory effects against TAA hepatic fibrosis in rats. Hesperidin (Hesp), is a pharmacologically active flavonoid, found abundantly in citrus species. Our present research attempts to inspect the potential hepatoprotective role of Hesp against thioacetamide (TAA)-induced hepatic fibrosis. Thirty-two male albino rats were split up into four equal groups, each with eight rats: Cont group was treated with ip saline. Every other day, the TAA group was injected 100\u2009mg\/kg BW ip TAA, Hesp group received every day oral Hesp 200\u2009mg\/kg BW as well as TAA\u2009+\u2009Hesp group received both therapies (TAA, Hesp) for eight successive weeks. Hesp in TAA treated group reduces ALT, AST, and ALP activities, total, direct bilirubin, total cholesterol, and triglycerides, meanwhile TP, Alb, globulin, A\/G ratio levels were insignificantly differed. The antioxidant capacity of Hesp was pronounced by a marked reduction in MDA level. While the antioxidant markers (SOD, CAT, GSH) were insignificantly changed after Hesp treatment. A strong significant correlation in treated rats between fibrosis score and CD34 and FGF23 gene expression. Liver sections from dual-treated rats showed a moderately decreased hepatic lesion and the dense, bluish-stained fibrous tissue by Masson\u2019s trichrome. Elevated gene expressions of CD34 and FGF23 after TAA hepatotoxicity were diminished by the antifibrotic effect of Hesp. Also, immunohistochemical expression showed reduction of TGF-\u03b2 and \u03b1-SMA in hepatocytes in the dual therapy group. Hesp possesses a potent antioxidant, and antifibrotic activities against TAA induced hepatic fibrosis by modulating TGF-\u03b2\/\u03b1-SMA pathways.<\/jats:p>","DOI":"10.1177\/03946320241309004","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T06:21:38Z","timestamp":1734762098000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Hesperidin ameliorates thioacetamide-induced liver fibrosis via antioxidative and anti-inflammatory mechanisms targeting TGF-\u03b2\/\u03b1-SMA pathways in rats"],"prefix":"10.1177","volume":"38","author":[{"given":"Aya","family":"Megahed","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Veterinary Medicine Faculty, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-2696","authenticated-orcid":false,"given":"Hossam","family":"Gadalla","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Veterinary Medicine Faculty, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheed A","family":"Filimban","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat A","family":"Albukhari","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Sembawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab M","family":"Bagadood","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadir","family":"Sindi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sciences Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-6828","authenticated-orcid":false,"given":"Fatma M","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Veterinary Medicine Faculty, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-1600","authenticated-orcid":false,"given":"Mohamed E","family":"El-Boshy","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Veterinary Medicine Faculty, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1653-1423","authenticated-orcid":false,"given":"Engy F","family":"Risha","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Veterinary Medicine Faculty, University of Mansoura, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"bibr1-03946320241309004","doi-asserted-by":"publisher","DOI":"10.3109\/15569543.2013.805144"},{"key":"bibr2-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00284-3"},{"issue":"3","key":"bibr3-03946320241309004","first-page":"340","volume":"10","author":"Uskokovi\u0107-Markovi\u0107 S","year":"2007","journal-title":"Journal of Pharmaceutical Sciences"},{"issue":"8","key":"bibr4-03946320241309004","first-page":"1088","volume":"29","author":"Ramaiah SK","year":"2001","journal-title":"Drug Metabolism and Disposition"},{"key":"bibr5-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90564.2008"},{"key":"bibr6-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.09.023"},{"key":"bibr7-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-56"},{"key":"bibr8-03946320241309004","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.75673"},{"issue":"10","key":"bibr9-03946320241309004","volume":"9","author":"Abdulaziz Bardi D","year":"2014","journal-title":"PLoS ONE"},{"key":"bibr10-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104200"},{"key":"bibr11-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1002\/term.2940"},{"key":"bibr12-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13665"},{"key":"bibr13-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1231695"},{"key":"bibr14-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.07.037"},{"key":"bibr15-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01843-z"},{"key":"bibr16-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-020-00344-x"},{"key":"bibr17-03946320241309004","first-page":"1","author":"Alkadhim AA","year":"2021","journal-title":"Annals of the Romanian Society for Cell Biology"},{"key":"bibr18-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.4723"},{"key":"bibr19-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.07.052"},{"key":"bibr20-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.09.007"},{"key":"bibr21-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-010-9494-5"},{"key":"bibr22-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320808110"},{"key":"bibr23-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4683"},{"key":"bibr24-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-85"},{"key":"bibr25-03946320241309004","volume-title":"Theory and practice of histological techniques","author":"Bancroft JD","year":"2008"},{"key":"bibr26-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"bibr27-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0445"},{"key":"bibr28-03946320241309004","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030369"},{"key":"bibr29-03946320241309004","volume-title":"SPSS 14.0 guide to data analysis","author":"Noru\u0161is MJ","year":"2006"},{"key":"bibr30-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.02.015"},{"key":"bibr31-03946320241309004","doi-asserted-by":"publisher","DOI":"10.4236\/jct.2013.41032"},{"key":"bibr32-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2015-133715"},{"key":"bibr33-03946320241309004","doi-asserted-by":"publisher","DOI":"10.56431\/p-ha9scc"},{"issue":"7","key":"bibr34-03946320241309004","volume":"7","author":"Sukalingam K","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"bibr35-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23353"},{"key":"bibr36-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.08.016"},{"key":"bibr37-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.05.020"},{"key":"bibr38-03946320241309004","doi-asserted-by":"publisher","DOI":"10.3390\/pr10081613"},{"key":"bibr39-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2014.11.003"},{"key":"bibr40-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.06.018"},{"key":"bibr41-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.07.026"},{"key":"bibr42-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9990091"},{"key":"bibr43-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.01.052"},{"key":"bibr44-03946320241309004","first-page":"456","volume":"27","author":"Abd-Elrahman NM","year":"2014","journal-title":"Benha Veterinary Medical Journal"},{"key":"bibr45-03946320241309004","doi-asserted-by":"publisher","DOI":"10.3390\/md17060317"},{"key":"bibr46-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12622"},{"key":"bibr47-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00344-3"},{"key":"bibr48-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.08.019"},{"key":"bibr49-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejbas.2014.12.005"},{"key":"bibr50-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24407"},{"key":"bibr51-03946320241309004","doi-asserted-by":"publisher","DOI":"10.21608\/smj.2017.34044"},{"key":"bibr52-03946320241309004","doi-asserted-by":"publisher","DOI":"10.5772\/26853"},{"key":"bibr53-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8323747"},{"key":"bibr54-03946320241309004","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11623"},{"key":"bibr55-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231905"},{"key":"bibr56-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264743"},{"key":"bibr57-03946320241309004","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.05.26"},{"key":"bibr58-03946320241309004","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11030175"},{"key":"bibr59-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12377"},{"key":"bibr60-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27332"},{"key":"bibr61-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.192"},{"key":"bibr62-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-0968-2"},{"key":"bibr63-03946320241309004","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.013"},{"issue":"13","key":"bibr64-03946320241309004","first-page":"2639","volume":"40","author":"Wu F","year":"2015","journal-title":"Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320241309004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03946320241309004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320241309004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:00:59Z","timestamp":1777456859000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03946320241309004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":64,"alternative-id":["10.1177\/03946320241309004"],"URL":"https:\/\/doi.org\/10.1177\/03946320241309004","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"03946320241309004"}}