{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:42:55Z","timestamp":1777711375383,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Although, several studies have assessed the association of HLA Class I and II genes with inclusion body myositis (IBM), results were inconsistent and between-studies heterogeneity needs to be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this review was to summarize existing data on the contribution of HLA-DRB1 and HLA-B alleles to IBM susceptibility and to investigate the between-studies heterogeneity by subgroup analyses and meta-regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This study was performed according to the PRISMA guidelines for systematic reviews and meta-analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An electronic literature search for eligible studies among all papers published prior to January 29, 2025, was conducted through PubMed, EMBASE, Web of science, and Scopus databases. Meta-analyses together with subgroup analyses and meta-regressions were performed for the two following HLA genes: HLA-DRB1 and HLA-B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Combined analyses revealed a significant increase in IBM risk conferred by the HLA-DRB1*03 allele (9.21 (7.05\u201312.01)), the DRB*03:01 allele (8.44 (6.85\u201310.41)), the DRB1*01 allele (2.31 (1.82\u20132.93)), the DRB1*01:01 allele (2.63 (1.95\u20133.55)), the DRB1*15:02 allele (3.49 (2.12\u20135.75)), the B*08 allele (4.05 (2.58\u20136.38)), and the DQB1*02 allele (6.62 (4.5\u20139.74)), all p-values\u2009&lt;\u20090.001. In addition, the DRB1*15:01 allele was found to be protective against IBM in all populations (0.48 (0.32\u20130.72)). Conversely, the DRB*11 allele was not associated with IBM risk, OR (95% CI)\u2009=\u20090.91 (0.54\u20131.51), p\u2009=\u20090.703.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This meta-analysis demonstrated that HLA-DRB1, DQB1, and B loci could play a major role in IBM pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>This review has been registered on PROSPERO on June 25, 2024: CRD42024557948, Available from: https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42024557948<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320251321747","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T06:07:11Z","timestamp":1739772431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of HLA-DR, HLA-DQ, and HLA-B alleles with inclusion body myositis risk: A systematic review, a meta-analysis, a meta-regression and a trial sequential analysis"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-0950","authenticated-orcid":false,"given":"Tarak","family":"Dhaouadi","sequence":"first","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awatef","family":"Riahi","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u00efeb","family":"Ben Abdallah","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousr","family":"Gorgi","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Sfar","sequence":"additional","affiliation":[{"name":"Research Laboratory in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"bibr1-03946320251321747","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-018-0738-0"},{"key":"bibr2-03946320251321747","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000431"},{"key":"bibr3-03946320251321747","doi-asserted-by":"publisher","DOI":"10.1515\/med-2015-0030"},{"key":"bibr4-03946320251321747","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206691"},{"key":"bibr5-03946320251321747","doi-asserted-by":"publisher","DOI":"10.1007\/s13317-016-0088-8"},{"key":"bibr6-03946320251321747","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.5.484"},{"issue":"2","key":"bibr7-03946320251321747","volume":"25","author":"Aouizerate J","year":"2015","journal-title":"Neuromuscular Disease"},{"key":"bibr8-03946320251321747","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2011.300630"},{"key":"bibr9-03946320251321747","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. 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