{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:10:59Z","timestamp":1787317859049,"version":"build-2736575974"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Liuzhou Science and Technology Plan Project","award":["2024YB0103B003"],"award-info":[{"award-number":["2024YB0103B003"]}]},{"name":"Natural Science Foundation of Sichuan Province of China","award":["2022NSFSC0046"],"award-info":[{"award-number":["2022NSFSC0046"]}]},{"name":"Sichuan Science and Technology Program","award":["2022YFS0631"],"award-info":[{"award-number":["2022YFS0631"]}]},{"name":"Self-funded Research Project of Guangxi Autonomous Region","award":["Z-B20241275; GXZYB20240601"],"award-info":[{"award-number":["Z-B20241275; GXZYB20240601"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Acute respiratory distress syndrome (ARDS) is a severe pulmonary condition characterized by inflammation and lung damage, frequently resulting in poor clinical outcomes. Recent studies suggest that the gut-lung axis, mediated by gut microbiota, is critical in ARDS progression. This study investigates the therapeutic potential of fecal microbiota transplantation (FMT) in an ARDS rat model (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20096).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The pathogenesis of ARDS involves complex interactions between the lungs and gut, with microbiota playing a key role. Understanding the effects of FMT on lung function and gut microbiota may provide new therapeutic strategies for ARDS management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sprague-Dawley rats were pre-treated with a broad-spectrum antibiotic cocktail to create a germ-free state and subsequently exposed to intranasal lipopolysaccharide to induce ARDS. The rats then received FMT treatment. Lung samples were analyzed using histopathology and transcriptomics. Fecal samples were analyzed using 16S rRNA sequencing and metabolomics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      FMT treatment significantly reduced lung injury and improved pulmonary function, as evidenced by increased partial pressure of arterial oxygen (PaO\n                      <jats:sub>2<\/jats:sub>\n                      ) and decreased partial pressure of arterial carbon dioxide (PaCO\n                      <jats:sub>2<\/jats:sub>\n                      ). FMT also significantly altered in gut microbiota composition by regulating the gut microbiota composition of\n                      <jats:italic toggle=\"yes\">Akkermansia<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Lactobacillus<\/jats:italic>\n                      , restoring the abundance of genera such as\n                      <jats:italic toggle=\"yes\">Muribaculaceae<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Clostridia_UCG-014<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Adlercreutzia<\/jats:italic>\n                      , while reducing\n                      <jats:italic toggle=\"yes\">Romboutsia<\/jats:italic>\n                      . FMT restored key metabolic pathways involved in lipid metabolism, amino acid biosynthesis, and immune regulation, including the modulation of immune pathways like mTOR signaling. These alterations contribute to reduced lung injury and improved pulmonary function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings indicate that FMT may exert its beneficial effects in ARDS by modulating the gut microbiota and enhancing metabolic and immune responses. However, given that this study remains in the preclinical stage, further validation in clinical studies is necessary before considering clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320251333982","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:01:17Z","timestamp":1745391677000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of fecal microbiota transplantation on lung function and gut microbiome in an ARDS rat model: A multi-omics analysis including 16S rRNA sequencing, metabolomics, and transcriptomics"],"prefix":"10.1177","volume":"39","author":[{"given":"Dongwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Inflammation &amp; Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People\u2019s Hospital, Guangxi Medical University, Liuzhou, Guangxi, China"},{"name":"Key Laboratory of Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People\u2019s Hospital, Guangxi Medical University, Liuzhou, Guangxi, China"},{"name":"Key Laboratory of Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiong","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Inflammation &amp; Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People\u2019s Hospital, Guangxi Medical University, Liuzhou, Guangxi, China"},{"name":"Key Laboratory of Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Inflammation &amp; Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People\u2019s Hospital, Guangxi Medical University, Liuzhou, Guangxi, China"},{"name":"Key Laboratory of Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Liuzhou People\u2019s Hospital, Guangxi Medical University, Liuzhou, Guangxi, China"},{"name":"Key Laboratory of Diagnosis, Treatment and Research of Asthma and Chronic Obstructive Pulmonary Disease, Liuzhou, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7404-7682","authenticated-orcid":false,"given":"Xianming","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"},{"name":"Inflammation &amp; Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0558WS"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06809-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01439-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000528914"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.24491"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04966-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05006-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116773"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241748"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2024.102316"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1330021"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15224734"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1333209"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0310180"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2022.102380"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2024.105341"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1243102"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v15.i9.908"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155190"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1366"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06410-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98053-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05000-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2024.5479"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-020-2062-4"},{"key":"e_1_3_2_28_2","first-page":"1582","article-title":"Effects and mechanism of fecal transplantation on acute lung injury induced by lipopolysaccharide in rats","volume":"99","author":"Yin GF","year":"2019","unstructured":"Yin GF, Li B, Fan XM (2019) Effects and mechanism of fecal transplantation on acute lung injury induced by lipopolysaccharide in rats. Zhonghua Yi Xue Za Zhi 99: 1582\u20131587.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107272"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110318"},{"key":"e_1_3_2_31_2","first-page":"346","article-title":"Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents","volume":"59","author":"Pang D","year":"2020","unstructured":"Pang D, Laferriere C (2020) Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents. Journal of the American Association for Laboratory Animal 59: 346.","journal-title":"Journal of the American Association for Laboratory Animal"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5321"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S459496"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123305"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050793"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114985"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.711055"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113810"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8060941"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03574-23"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201702-0441OC"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002612"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173848"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13010016"},{"key":"e_1_3_2_45_2","article-title":"Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile)","volume":"4","author":"Minkoff NZ","year":"2023","unstructured":"Minkoff NZ, Aslam S, Medina M, et al (2023) Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile). The Cochrane Database of Systematic Reviews 4: CD013871.","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43716"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05317-1"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-01975-x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-024-0433-x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060842"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109872"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176356"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO04051H"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0325"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105548"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.870094"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO01929B"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201907-1487OC"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154656"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108782"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-024-04130-3"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2002.02044"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01964-3"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42616"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.09.001"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320251333982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03946320251333982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320251333982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:01:07Z","timestamp":1777456867000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03946320251333982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":64,"alternative-id":["10.1177\/03946320251333982"],"URL":"https:\/\/doi.org\/10.1177\/03946320251333982","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"article-number":"03946320251333982"}}