{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:52:00Z","timestamp":1784022720195,"version":"3.55.0"},"reference-count":56,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma","award":["2020Y2014"],"award-info":[{"award-number":["2020Y2014"]}]},{"DOI":"10.13039\/501100003392","name":"The Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J011535"],"award-info":[{"award-number":["2023J011535"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the role of glutathione peroxidase 7 (GPX7) in mitigating oxidative stress-induced cellular ageing and its contribution to intervertebral disc degeneration (IVDD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Human nucleus pulposus (NP) cells in degenerated intervertebral discs (IVDs) show signs of ageing, such as telomere shortening, DNA damage, and mitochondrial dysfunction. GPX7, known for its ability to protect against ageing in cancer cells, may also play a role in NP cell ageing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Two datasets (GSE34095 and GSE147383) were analysed to compare GPX7 expression in normal and degenerated IVDs and used KEGG analysis to identify related pathways. An H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      -induced cell model and a natural ageing model were used to simulate ageing. GPX7 was transfected into and overexpressed in NP cells, and its protective effects were examined. Molecular docking identified GNF-5837 as a potential compound to prevent GPX7 cleavage, which was tested in an IVDD rat model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The expression of GPX7 was increased in degenerated IVDs and H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      -induced models. GPX7 overexpression reduced ageing in NP cells. GNF-5837 alleviated IVDD in rats by upregulating GPX7.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study demonstrates that GNF-5837 reduced the expression of ageing markers by upregulating GPX7, suggesting it could serve as a potential treatment for IVDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320251343365","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:12:56Z","timestamp":1749179576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7"],"prefix":"10.1177","volume":"39","author":[{"given":"Yangkai","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-8500","authenticated-orcid":false,"given":"Weihong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35041687"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.116"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0457-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103361"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1365-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00733-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.160"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309032"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyw078"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041579"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45359"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30970-9"},{"key":"e_1_3_3_14_2","first-page":"10","article-title":"Histology and pathology of the human intervertebral disc","volume":"88","author":"Roberts S","year":"2006","unstructured":"Roberts S, Evans H, Trivedi J, et al. (2006) Histology and pathology of the human intervertebral disc. The Journal of Bone and Joint Surgery American Volume 88 (Suppl. 2): 10\u201314.","journal-title":"The Journal of Bone and Joint Surgery American Volume"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25453-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00713-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100978"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106841"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134091"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"issue":"39","key":"e_1_3_3_21_2","article-title":"Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo","volume":"61","author":"Luo T","year":"2022","unstructured":"Luo T, Zheng Q, Shao L, et al. (2022) Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo. Angewandte Chemie International Edition in English 61(39): e202206277.","journal-title":"Angewandte Chemie International Edition in English"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.196"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.146290"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301078"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-014-0189-1"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304612"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109578"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.006"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091329"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117345"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.07.011"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1284"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.046"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000004486"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25167"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-1274OC"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7142"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23136960"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031080"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205588"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.1025"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00732-0"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2004.03.025"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.01.017"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.001"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2018"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109099"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.06.099"},{"issue":"32","key":"e_1_3_3_49_2","article-title":"Circadian clock regulation via biomaterials for nucleus pulposus","volume":"35","author":"Chen W","year":"2023","unstructured":"Chen W, Zheng D, Chen H, et al. (2023) Circadian clock regulation via biomaterials for nucleus pulposus. Advanced Materials 35(32): e2301037.","journal-title":"Advanced Materials"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04632-z"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03596-w"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.86665"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-05094-y"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2019.1664038"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063102"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.953013"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c03894"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320251343365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03946320251343365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320251343365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:01:08Z","timestamp":1777456868000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03946320251343365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":56,"alternative-id":["10.1177\/03946320251343365"],"URL":"https:\/\/doi.org\/10.1177\/03946320251343365","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"article-number":"03946320251343365"}}