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The aim was to evaluate whether lymphocyte numbers also decrease in the spleen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>CBD, the major non-psychotropic compound of Cannabis sp., is an effective treatment for inflammatory and autoimmune diseases with various anti-tumor effects, but the mechanisms of its long-term actions in vivo remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      To examine the effects of CBD on lymphocyte subsets in the spleen and NK cellular cytotoxicity (NKCC), adult male Wistar rats (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 63) were administered intraperitoneal injections of CBD (2.5 or 5 mg\/kg\/day) for 14 consecutive days, and lymphocyte counts were obtained using flow cytometry. NKCC in the peripheral blood and spleen was quantified using a Chromium-51 release assay. Furthermore, the effect was similar to a decrease in lymphocytes caused by treatment with the selective receptor antagonist AM630 (1 mg\/kg).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results indicate that repeated administration of CBD at a dose of 5 mg\/kg\/day decreased splenic lymphocyte numbers, involving T and non-T\/NK CD45RA+ lymphocytes but not NK cells. The effects of CB\n                      <jats:sub>2<\/jats:sub>\n                      receptor antagonist were not significant, but it had a significant interaction with CBD. No changes in NKCC were observed following CBD administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results reveal that in healthy rats, CBD produces similar lymphopenic effects in the spleen as it does in peripheral blood without affecting NK cell counts or cytotoxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320251411441","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:06:28Z","timestamp":1767920788000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-6043","authenticated-orcid":false,"given":"Tara 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