{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:43:49Z","timestamp":1777711429767,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Kweichow Moutai Hospital research project","award":["MTyk 2022-17"],"award-info":[{"award-number":["MTyk 2022-17"]}]},{"name":"Kweichow Moutai Hospital research project","award":["MTyk2024-31"],"award-info":[{"award-number":["MTyk2024-31"]}]},{"name":"Zunyi Science and Technology Bureau Science and Technology Fund Project","award":["(2023) No. 199"],"award-info":[{"award-number":["(2023) No. 199"]}]},{"name":"Zunyi Science and Technology Bureau Science and Technology Fund Project","award":["(2023) No. 221"],"award-info":[{"award-number":["(2023) No. 221"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460373"],"award-info":[{"award-number":["82460373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["ZK-2023-544"],"award-info":[{"award-number":["ZK-2023-544"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["ZK-2024-299"],"award-info":[{"award-number":["ZK-2024-299"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","award":["gzwkj2024-310"],"award-info":[{"award-number":["gzwkj2024-310"]}],"id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury characterized by damage to alveolar epithelial cells and pulmonary capillary endothelial cells. Compared with ARDS caused by other causes, the subtypes of ARDS caused by sepsis are more serious and lead to poor prognosis and higher mortality. Agmatine (AGM) is a biological metabolite of L-arginine decarboxylation, proven to ameliorate sepsis-induced acute lung injury (SALI), but the mechanism remains unclear. Therefore, this study aims to explore the role of AGM in SALI, clarify the relationship between the I\n                    <jats:sub>2<\/jats:sub>\n                    R\/RSK2\/NF-\u03baB signaling pathway regulated by AGM and macrophage polarization, and provide a theoretical basis for the clinical treatment of SALI. Cellular and animal models of lung injury in sepsis were established with lipopolysaccharide (LPS). We conducted a series of experiments to examine the oxygenation index (OI), wet\/dry ratio (W\/D) of the lung, pathological changes, levels of inflammation, Apoptosis and related protein expression in different groups of mice. Finally, we found that AGM can ameliorate sepsis-induced acute lung injury by suppressing the I\n                    <jats:sub>2<\/jats:sub>\n                    R\/RSK2\/NF-\u03baB signaling pathway and modulating polarization of alveolar macrophage.\n                  <\/jats:p>","DOI":"10.1177\/03946320261425360","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:14:16Z","timestamp":1771845256000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Agmatine suppresses the imidazoline I\n                    <sub>2<\/sub>\n                    receptor\/ribosomal S6 kinase 2\/NF-\u03baB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury"],"prefix":"10.1177","volume":"40","author":[{"given":"Linguo","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Dai","sequence":"additional","affiliation":[{"name":"Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangjie","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-5580","authenticated-orcid":false,"given":"Hong","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4547-1901","authenticated-orcid":false,"given":"Liting","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Kweichow Moutai Hospital, Renhuai, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001303"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01722"},{"key":"e_1_3_2_6_2","article-title":"The role of macrophages polarization in sepsis-induced acute lung injury","volume":"14","author":"Wang Z","year":"2023","unstructured":"Wang Z, Wang Z (2023) The role of macrophages polarization in sepsis-induced acute lung injury. Frontiers in Immunology 14: 1209438.","journal-title":"Frontiers in Immunology"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7906055"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1304.004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154957"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.08.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004065"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.164"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-018-0280-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.137804"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.01.022"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.058"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.06.086"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.10.007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03775-3"},{"key":"e_1_3_2_20_2","article-title":"How to calculate sample size in animal and human studies","volume":"10","author":"Zhang X","year":"2023","unstructured":"Zhang X, Hartmann P (2023) How to calculate sample size in animal and human studies. Frontiers in Medicine 10: 1215927.","journal-title":"Frontiers in Medicine"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0531ST"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04699-w"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1277161"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.7560"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102655"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004155"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415784"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2005.10310.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2019.05.001"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003161"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S357012"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2023.119535"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102056"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000530307"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb14988.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170007"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01741-z"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2023.2292256"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01022-x"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320261425360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03946320261425360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320261425360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:01:16Z","timestamp":1777456876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03946320261425360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":40,"alternative-id":["10.1177\/03946320261425360"],"URL":"https:\/\/doi.org\/10.1177\/03946320261425360","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"article-number":"03946320261425360"}}