{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:03:19Z","timestamp":1779696199009,"version":"3.53.1"},"reference-count":77,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005595","name":"university of california","doi-asserted-by":"publisher","award":["Start Up Fund 101"],"award-info":[{"award-number":["Start Up Fund 101"]}],"id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Infections with human herpesviruses are known to be associated with oral lesions and other oral complications. For example, herpes simplex virus 1 (HSV-1) is the causative agent for cold sores. Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) causes oral Kaposi\u2019s sarcoma (KS) and other oral complications among immunocompromised patients, such as HIV-positive individuals. Novel antiviral strategies are needed to effectively treat oral infections caused by HSV-1 and KSHV, given the limitations of current FDA-approved anti-HSV-1 and anti-KSHV therapies. Nucleic acid-based gene-interfering molecules, such as antisense oligonucleotides, ribozymes, and small interfering RNA (siRNA), are promising gene-targeting agents for therapeutic applications. Ribozymes derived from the catalytic RNA subunit of RNase P in\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    represent a novel class of RNA-based gene targeting molecules for degrading target mRNAs and modulating gene expression. Methods have been developed to engineer RNase P ribozymes that more effectively suppress gene expression. In this review, we summarize the recent advances in using RNase P ribozymes to block the expression of HSV-1 and KSHV genes and inhibit the infection of HSV-1 and KSHV. Moreover, we discuss the potential of engineered RNase P ribozymes as therapeutics to treat infections and associated diseases caused by HSV-1 and KSHV in the oral cavity.\n                  <\/jats:p>","DOI":"10.1177\/03946320261451393","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:06:46Z","timestamp":1779512806000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of RNase P ribozyme-based therapy against oral herpesvirus infections by HSV-1 and KSHV"],"prefix":"10.1177","volume":"40","author":[{"given":"Thomas","family":"Sorrell","sequence":"first","affiliation":[{"name":"School of Public Health, University of California, Berkeley, CA, USA"},{"name":"Department of Molecular Cell Biology, University of California, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-1745","authenticated-orcid":false,"given":"Fenyong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California, Berkeley, CA, USA"},{"name":"Program in Comparative Biochemistry, University of California, Berkeley, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio233035a0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90117-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107318"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1697102"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2443980"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.4.471"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28083619"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100101797"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11030654"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403059200"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.731.003k28_731_737"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051855"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014975108"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27776"},{"key":"e_1_3_3_17_2","first-page":"235","volume-title":"Fields Virology: DNA Viruses","author":"Knipe DM","year":"2021","unstructured":"Knipe DM, Heldwein EE, Mohr IJ, et al. 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