{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:38:09Z","timestamp":1792269489259,"version":"4.4.0"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunopathol Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypersensitivity reactions to carboplatin include type I reactions, mixed reactions, and delayed reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a case of an atypical cytokine release syndrome induced by carboplatin in a patient with breast carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management &amp; outcome<\/jats:title>\n                    <jats:p>The patient developed clinical manifestations consisting of a delayed cytokine release syndrome following administration of carboplatin and paclitaxel. To establish the diagnosis, she underwent a double desensitization protocol over two consecutive days with paclitaxel and carboplatin. A delayed elevation of interleukin-6 after carboplatin supported the diagnosis of an isolated cytokine release syndrome. The patient subsequently continued treatment with paclitaxel through standard infusions and with carboplatin using a desensitization protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Cytokine release syndrome associated with carboplatin has been previously reported as occurring immediately after infusion and as part of a mixed phenotype (type I and cytokine release). A delayed-onset cytokine release syndrome induced by carboplatin, occurring outside the context of a mixed reaction, is reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cytokine release syndrome may present as an isolated, delayed reaction following carboplatin infusion. Measurement of interleukin-6 may be a valuable diagnostic tool for confirming the diagnosis of cytokine release syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03946320261472669","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:42:40Z","timestamp":1790001760000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Atypical cytokine release syndrome induced by carboplatin: The first described case report"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1859-143X","authenticated-orcid":false,"given":"Maria Cruz","family":"Torres G\u00f3rriz","sequence":"first","affiliation":[{"name":"General University Hospital of Castell\u00f3n"},{"name":"Jaume I University"},{"name":"FISABIO Foundation Research Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Borr\u00e1s Cuartero","sequence":"additional","affiliation":[{"name":"Castellon Provincial Hospital Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bosh Requena","sequence":"additional","affiliation":[{"name":"University Clinical Hospital of Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dah Tay","family":"Jang","sequence":"additional","affiliation":[{"name":"General University Hospital of Castell\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Enrique","sequence":"additional","affiliation":[{"name":"General University Hospital of Castell\u00f3n"},{"name":"Jaume I University"},{"name":"FISABIO Foundation Research Group"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15940"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0712"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.04.015"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2021.12.004"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0860"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14134723"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx216"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552231204367"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220980813"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14644"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1471038"}],"container-title":["International Journal of Immunopathology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320261472669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03946320261472669","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03946320261472669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:32:18Z","timestamp":1790260338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03946320261472669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":11,"alternative-id":["10.1177\/03946320261472669"],"URL":"https:\/\/doi.org\/10.1177\/03946320261472669","relation":{},"ISSN":["0394-6320","2058-7384"],"issn-type":[{"value":"0394-6320","type":"print"},{"value":"2058-7384","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"03946320261472669"}}