{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:34:42Z","timestamp":1790386482983,"version":"4.1.0"},"reference-count":116,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Challenges for the clinical management of bipolar disorder (BD) during pregnancy are multiple and complex and include competing risks to mother and offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We reviewed recent research findings on the course of BD during pregnancy and postpartum, as well as reproductive safety data on the major mood stabilizers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Pregnancy, and especially the postpartum period, are associated with a high risk for recurrence of BD. This risk appears to be limited by mood-stabilizing treatments and markedly increased by the abrupt discontinuation of such treatments. However, drugs used to treat or protect against recurrences of BD vary markedly in teratogenic potential: there are low risks with typical neuroleptics, moderate risks with lithium, higher risks with older anticonvulsants such as valproic acid and carbamazepine, and virtually unknown risks with other newer-generation anticonvulsants and atypical antipsychotics (ATPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Clinical management of BD through pregnancy and postpartum calls for balanced assessments of maternal and fetal risks and benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Contexte:<\/jats:title>\n                    <jats:p>Les probl\u00e8mes li\u00e9s au traitement clinique du trouble bipolaire (TB) durant la grossesse sont profonds et peuvent entra\u00eener des risques concurrents pour la m\u00e8re et l'enfant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thode:<\/jats:title>\n                    <jats:p>Nous avons examin\u00e9 les r\u00e9sultats r\u00e9cents de la recherche sur le cours du TB durant la grossesse et le post-partum, de m\u00eame que les donn\u00e9es d'innocuit\u00e9 reproductrice des principaux r\u00e9gulateurs de l'humeur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultats:<\/jats:title>\n                    <jats:p>La grossesse et surtout la p\u00e9riode du post-partum comportent des risques \u00e9lev\u00e9s de r\u00e9currence du TB. Les risques semblent \u00eatre limit\u00e9s par les traitements aux r\u00e9gulateurs de l'humeur et notablement accrus par la cessation abrupte de ces traitements. Toutefois, les m\u00e9dicaments utilis\u00e9s pour traiter ou pr\u00e9venir les r\u00e9currences du TB varient beaucoup en ce qui concerne les risques t\u00e9ratog\u00e8nes: les risques sont faibles pour les neuroleptiques typiques, mod\u00e9r\u00e9s pour le lithium, \u00e9lev\u00e9s pour les anciens anticonvulsivants comme l'acide valpro\u00efque et la carbamaz\u00e9pine, et presque inconnus pour les autres anticonvulsivants de la nouvelle g\u00e9n\u00e9ration et les antipsychotiques atypiques (APA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Le traitement clinique des femmes souffrant du TB durant la grossesse et le post-partum demande des \u00e9valuations \u00e9quilibr\u00e9es des risques et des avantages pour la m\u00e8re et le foetus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370204700503","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T19:05:00Z","timestamp":1484075100000},"page":"426-436","source":"Crossref","is-referenced-by-count":99,"title":["Managing Bipolar Disorder during Pregnancy: Weighing the Risks and Benefits"],"prefix":"10.1177","volume":"47","author":[{"given":"Adele C","family":"Viguera","sequence":"first","affiliation":[{"name":"Associate Director, Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital; Instructor in Psychiatry, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S","family":"Cohen","sequence":"additional","affiliation":[{"name":"Director, Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital; Associate Professor of Psychiatry, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross J","family":"Baldessarini","sequence":"additional","affiliation":[{"name":"Director, Bipolar and Psychotic Disorders and Psychopharmacology Programs, Laboratories for Psychiatric Research, and International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital; Professor of Psychiatry and, Neuroscience, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Nonacs","sequence":"additional","affiliation":[{"name":"Instructor in Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"bibr1-070674370204700503","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950010008002"},{"key":"bibr2-070674370204700503","doi-asserted-by":"publisher","DOI":"10.1002\/0471234311.ch17"},{"key":"bibr3-070674370204700503","volume-title":"Manic-depressive illness","author":"Goodwin FK","year":"1990"},{"key":"bibr4-070674370204700503","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.5.720"},{"key":"bibr5-070674370204700503","first-page":"652","volume":"39","author":"Dion GL","year":"1988","journal-title":"Hospital and Community Psychiatry"},{"key":"bibr6-070674370204700503","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.11.1635"},{"key":"bibr7-070674370204700503","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.220"},{"key":"bibr8-070674370204700503","unstructured":"Tondo L, Isaacsson G, Baldessarinin RJ. 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