{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:01:50Z","timestamp":1790985710405,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Previous proton magnetic resonance spectroscopy (\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS) studies in posttraumatic stress disorder (PTSD) report decreased hippocampal N-acetylaspartate (NAA), an indicator of neuronal integrity. However, other areas of the brain need to be explored. The objective of this study was to investigate the specificity of hippocampal NAA concentration changes in PTSD by also examining a control region, the occipital white matter (OWM).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Eight patients with PTSD and 5 control subjects underwent single-voxel\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS of the hippocampi and bilateral OWM. Absolute neurometabolite concentrations were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Preliminary Results:<\/jats:title>\n                    <jats:p>Trends toward reduced left hippocampal NAA and creatine (Cre) were found in the PTSD group. PTSD subjects also had reduced bilateral OWM Cre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The preliminary results of our study in civilians with PTSD replicate previous MRS studies and are consistent with decreased hippocampal neuronal integrity without effects in the OWM. Replication of our findings is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370204700709","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T01:41:32Z","timestamp":1500514892000},"page":"666-670","source":"Crossref","is-referenced-by-count":67,"title":["Proton Magnetic Resonance Spectroscopy of the Hippocampus and Occipital White Matter in PTSD: Preliminary Results"],"prefix":"10.1177","volume":"47","author":[{"given":"Gerardo","family":"Villarreal","sequence":"first","affiliation":[{"name":"Staff Psychiatrist, PTSD Clinic, Veterans Administration Hospital; Assistant Professor Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Petropoulos","sequence":"additional","affiliation":[{"name":"Biomedical Engineer, Clinical and Magnetic Resonance Research Center, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Doctoral Candidate, Department of Psychology, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M","family":"Rowland","sequence":"additional","affiliation":[{"name":"Doctoral Candidate, Department of Psychology, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P","family":"Horan","sequence":"additional","affiliation":[{"name":"Post-Doctoral, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A","family":"Griego","sequence":"additional","affiliation":[{"name":"Research and Teaching Associate, Institute of Cognitive Science, University of Osnabrueck, Osnabrueck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Moreshead","sequence":"additional","affiliation":[{"name":"Graduate Student, Department of Psychology, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine L","family":"Hart","sequence":"additional","affiliation":[{"name":"Chief of Neuroradiology, University Hospital; Professor, Department of Radiology, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M","family":"Brooks","sequence":"additional","affiliation":[{"name":"Scientific Director, Clinical and Magnetic Resonance Research Center; Research Associate Professor, Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"bibr1-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.973"},{"key":"bibr2-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00229-6"},{"key":"bibr3-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00162-X"},{"key":"bibr4-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291797005242"},{"key":"bibr5-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01245-8"},{"key":"bibr6-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1022"},{"key":"bibr7-070674370204700709","volume-title":"Brian imaging in clinical psychiatry.","author":"Charles HC","year":"1997"},{"key":"bibr8-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-00981.1993"},{"key":"bibr9-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48319.x"},{"key":"bibr10-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400110"},{"key":"bibr11-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360302"},{"key":"bibr12-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<193::AID-MRM27>3.0.CO;2-P"},{"key":"bibr13-070674370204700709","volume-title":"Structured clinical interview for DSM-IV axis I diagnosis-patient edition (SCID-I\/P, version 2.0)","author":"First MB","year":"1996"},{"key":"bibr14-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1002\/jts.2490080106"},{"key":"bibr15-070674370204700709","first-page":"2323","volume":"24","author":"Brooks WM","year":"1997","journal-title":"J Rheumatol"},{"key":"bibr16-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199901)9:1<39::AID-JMRI5>3.0.CO;2-8"},{"key":"bibr17-070674370204700709","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"bibr18-070674370204700709","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00994-X"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370204700709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370204700709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:13:02Z","timestamp":1777392782000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/070674370204700709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1177\/070674370204700709"],"URL":"https:\/\/doi.org\/10.1177\/070674370204700709","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}