{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:01:09Z","timestamp":1777521669068,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To date, carbon dioxide (CO\n                      <jats:sub>2<\/jats:sub>\n                      ) challenge tests in panic disorder (PD) patients have focused on anxiety as the sole outcome measure. This study assesses a broader range of symptoms in patients with PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      We administered a gas mixture of 35% CO\n                      <jats:sub>2<\/jats:sub>\n                      and 65% oxygen (O\n                      <jats:sub>2<\/jats:sub>\n                      ) to 25 patients with PD. Nine patients met the criteria for a comorbid major depressive disorder (MDD), and 16 did not. We assessed not only subjects' symptoms of anxiety but also their symptoms of depression and aggression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baseline ratings did not differ across the 2 subgroups. Postchallenge ratings were higher for PD and MDD patients on all the assessed affective symptoms, except for specific panic symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      These findings suggest that, in addition to anxiety, CO\n                      <jats:sub>2<\/jats:sub>\n                      challenge induces depressive and aggressive symptoms, specifically in PD patients with comorbid depression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370505000307","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T21:50:54Z","timestamp":1483653054000},"page":"175-178","source":"Crossref","is-referenced-by-count":6,"title":["Experimental Affective Symptoms in Panic Disorder Patients"],"prefix":"10.1177","volume":"50","author":[{"given":"Thea","family":"Overbeek","sequence":"first","affiliation":[{"name":"Research Physician, Academic Anxiety Center, Psychiatric Hospital Vijverdal, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Schruers","sequence":"additional","affiliation":[{"name":"Assistant Professor of Psychiatry, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ine Docters","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Physician, University of Maastricht, Maastricht, the Nethetherlands. Psychiatrist, Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tineke","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Professor of Experimental Psychiatry, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Griez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"bibr1-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(87)90001-1"},{"key":"bibr2-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(98)00027-0"},{"key":"bibr3-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90510-9"},{"key":"bibr4-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(95)02723-A"},{"key":"bibr5-070674370505000307","first-page":"205","volume-title":"Comorbidity of mood and anxiety disorders","author":"Di Nardo PA","year":"1990"},{"key":"bibr6-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(90)90086-K"},{"key":"bibr7-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1998.tb05971.x"},{"key":"bibr8-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.7.867"},{"key":"bibr9-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1989.tb10294.x"},{"key":"bibr10-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00023-8"},{"key":"bibr11-070674370505000307","first-page":"22","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"bibr12-070674370505000307","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","edition":"4"},{"key":"bibr13-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(98)00009-2"},{"key":"bibr14-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1081"},{"key":"bibr15-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00117-7"},{"key":"bibr16-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1080\/026404199365425"},{"key":"bibr17-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(98)00004-3"},{"key":"bibr18-070674370505000307","volume-title":"Version 11.0","author":"Statistical Software Package for the Social Sciences","year":"2002"},{"key":"bibr19-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197607000-00007"},{"key":"bibr20-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(78)90002-8"},{"key":"bibr21-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.2.125"},{"key":"bibr22-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00335-3"},{"key":"bibr23-070674370505000307","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)00088-Q"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370505000307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370505000307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:15:07Z","timestamp":1777392907000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/070674370505000307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1177\/070674370505000307"],"URL":"https:\/\/doi.org\/10.1177\/070674370505000307","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}