{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:28:22Z","timestamp":1777519702154,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The etiology of delusional disorder is imperfectly understood. Involvement of biological factors has long been suspected. We examined the incidence of class I human leukocyte antigens (HLAs) in patients with delusional disorder to understand the role of HLA genes and explore a possible immunogenetic etiology for delusional disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used a nested case\u2013control study design. Psychiatric reference data were available for 27 500 patients registered between 1998 and 2003. Initially, we enrolled 150 patients with delusional disorder from the India-born Bengali population, using DSM-IV diagnostic criteria. After longitudinal follow-up, 80 patients were found to have only delusional disorder, while the remaining 70 patients represented different illnesses with paranoid symptoms and were excluded. We performed serological typing on all 150 patients and applied the polymerase chain reaction\u2013based high-resolution molecular typing method to the 80 patients with delusional disorder. Eighty healthy donors of the same ethnic background, matched for age, sex, and other socioeconomic variables, formed the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Some of the HLA alleles were associated with delusional disorder, and the gene HLA-A*03 was found to be significantly more frequent. This gene may influence patients' susceptibility to delusional disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study reveals important associations between HLA genes and delusional disorder. This preliminary observation may help our understanding of this disorder's genetic basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370505000507","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T15:24:31Z","timestamp":1483629871000},"page":"269-274","source":"Crossref","is-referenced-by-count":4,"title":["A Study of HLA-Linked Genes in a Monosymptomatic Psychotic Disorder in an Indian Bengali Population"],"prefix":"10.1177","volume":"50","author":[{"given":"Monojit","family":"Debnath","sequence":"first","affiliation":[{"name":"Senior Research Fellow, Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujit K","family":"Das","sequence":"additional","affiliation":[{"name":"Professor and Head, Department of Psychiatry, North Bengal Medical College and Hospital, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmal K","family":"Bera","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Psychiatry, North Bengal Medical College and Hospital, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitta R","family":"Nayak","sequence":"additional","affiliation":[{"name":"Systems' Engineer and Head, Computer Centre, University of North Bengal, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapas K","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Associate Professor, Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"bibr1-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/17.4.633"},{"key":"bibr2-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000296414"},{"key":"bibr3-070674370505000507","first-page":"1243","volume-title":"Comprehensive textbook of psychiatry","author":"Manchreck TC","year":"1999"},{"key":"bibr4-070674370505000507","first-page":"32","volume":"57","author":"Manchreck TC","year":"1996","journal-title":"J Clin Psychiatry"},{"key":"bibr5-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1177\/070674379704200608"},{"key":"bibr6-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1159\/000284484"},{"key":"bibr7-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1177\/070674378803300301"},{"key":"bibr8-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780300059007"},{"key":"bibr9-070674370505000507","first-page":"503","volume-title":"Synopsis of psychiatry","author":"Kaplan HI","year":"1994","edition":"7"},{"key":"bibr10-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1159\/000284426"},{"key":"bibr11-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1159\/000284877"},{"key":"bibr12-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000726"},{"key":"bibr13-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1321"},{"key":"bibr14-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991015)88:5<486::AID-AJMG10>3.0.CO;2-P"},{"key":"bibr15-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00421-3"},{"key":"bibr16-070674370505000507","first-page":"998","volume":"24","author":"Denburg SD","year":"1997","journal-title":"J Rheumatology"},{"key":"bibr17-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(96)82950-1"},{"key":"bibr18-070674370505000507","first-page":"296","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","edition":"4"},{"key":"bibr19-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1038\/204998b0"},{"key":"bibr20-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"bibr21-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"bibr22-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1974.tb00230.x"},{"key":"bibr23-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00022-0"},{"key":"bibr24-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1177\/070674378803300302"},{"key":"bibr25-070674370505000507","doi-asserted-by":"publisher","DOI":"10.1159\/000153604"},{"key":"bibr26-070674370505000507","first-page":"1064","volume-title":"HLA 1991. 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