{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:32:56Z","timestamp":1777519976060,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Benzodiazepines and similar sedative-hypnotics (BDZ-SSHs) are associated with both beneficial and adverse effects. Pharmacoepidemiologic data describing the use of these medications in contemporary Canadian populations has not been readily available. Our objective was to examine the hypothesis that increasing use of antidepressant medications for anxiety and mood disorders during the past decade led to less frequent use of BDZ-SSH medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We used data from an Alberta Mental Health Survey to describe the pattern of BDZ-SSH use and to estimate provincial and health region frequencies of use. We supplemented the data with pharmacy dispensing data from IMS Health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The frequency of use was comparable to that reported in previous studies. Unexpectedly, in the survey data, we observed trends suggesting regional variation both in the frequency and pattern of use. Examination of prescription dispensing data confirmed this pattern. Clinical factors, including the use of other psychotropic medications and psychiatric diagnoses, were strongly associated with BDZ-SSH use. Among the drugs examined, zopiclone had the highest frequency of use. Prescription dispensing data confirmed that the frequency of zopiclone use in Alberta is higher than that in most other provinces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This descriptive study generates several new research questions and provides benchmarks for future pharmacoepidemiologic monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Contexte:<\/jats:title>\n                    <jats:p>Les benzodiaz\u00e9pines et les s\u00e9datifs hypnotiques semblables (BDZ-SHS) sont associ\u00e9s \u00e0 des effets tant b\u00e9n\u00e9fiques qu'ind\u00e9sirables. Les donn\u00e9es pharmaco-\u00e9pid\u00e9miologiques d\u00e9crivant l'utilisation de ces m\u00e9dicaments dans les populations canadiennes contemporaines ne sont pas facilement disponibles. Nous avons \u00e9mis l'hypoth\u00e8se que l'utilisation croissante d'antid\u00e9presseurs pour les troubles anxieux et de l'humeur au cours de la derni\u00e8re d\u00e9cennie peut avoir entra\u00een\u00e9 une fr\u00e9quence d'utilisation plus faible des BDZ-SHS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thode:<\/jats:title>\n                    <jats:p>Dans cette \u00e9tude, nous avons utilis\u00e9 les donn\u00e9es d'une enqu\u00eate sur la sant\u00e9 mentale en Alberta pour d\u00e9crire le mod\u00e8le d'utilisation des BDZ-SHS et estimer les fr\u00e9quences d'utilisation \u00e0 l'\u00e9chelle de la province et de la r\u00e9gion sanitaire. Les donn\u00e9es ont \u00e9t\u00e9 compl\u00e9t\u00e9es par les donn\u00e9es d'IMS Health sur les pharmacies ex\u00e9cutant les ordonnances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultats:<\/jats:title>\n                    <jats:p>La fr\u00e9quence d'utilisation \u00e9tait comparable \u00e0 celle rapport\u00e9e dans les \u00e9tudes pr\u00e9c\u00e9dentes. Inopin\u00e9ment, des tendances sugg\u00e9rant une variation r\u00e9gionale de la fr\u00e9quence et du mod\u00e8le d'utilisation ont \u00e9t\u00e9 observ\u00e9es dans les donn\u00e9es de l'enqu\u00eate. L'examen des donn\u00e9es sur l'ex\u00e9cution des ordonnances confirmait ce mod\u00e8le. Les facteurs cliniques, incluant l'utilisation d'autres psychotropes et les diagnostics psychiatriques \u00e9taient fortement associ\u00e9s \u00e0 l'utilisation des BDZ-SHS. Parmi les m\u00e9dicaments examin\u00e9s, la zopiclone \u00e9tait le plus fr\u00e9quemment utilis\u00e9. L'examen des donn\u00e9es sur l'ex\u00e9cution des ordonnances confirmait que la fr\u00e9quence d'utilisation de la zopiclone en Alberta est plus \u00e9lev\u00e9e que celle de la plupart des autres provinces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Cette \u00e9tude descriptive donne lieu \u00e0 plusieurs nouvelles questions de recherche et fournit des rep\u00e8res \u00e0 la future surveillance pharmaco-\u00e9pid\u00e9miologique.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370605100504","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:51:10Z","timestamp":1484322670000},"page":"287-294","source":"Crossref","is-referenced-by-count":18,"title":["Sedative Hypnotic Use in Alberta"],"prefix":"10.1177","volume":"51","author":[{"given":"Aliya","family":"Kassam","sequence":"first","affiliation":[{"name":"Research 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