{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:33:22Z","timestamp":1777520002658,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Genetic associations between delusional disorder and paranoid schizophrenia are not well understood, although involvement of biological factors has been suspected. We investigated the incidence of human leukocyte antigen (HLA) class I alleles in patients with delusional disorder and paranoid schizophrenia, first, to explore a possible immunogenetic etiology of these paranoid disorders and, second, to determine whether they share similar etiologic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We employed a nested case\u2013control study design. Psychiatric reference data were available for 38500 patients attending a hospital-based psychiatric outpatient department between 1998 and 2005. We enrolled 100 patients with delusional disorder and 50 patients with paranoid schizophrenia as the subject cases, using DSM-IV criteria. We considered equivalent numbers of healthy volunteers matched for age and ethnic background as control subjects. All subjects came from an India-born Bengali population. We applied the polymerase chain reaction\u2013based molecular typing method to all patients and healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The HLA-A*03 gene is significantly associated with delusional disorder as well as with paranoid schizophrenia. This HLA gene alone or in linkage disequilibrium with other HLA genes or other closely linked non-HLA genes may influence susceptibility to delusional disorder and paranoid schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study reveals important associations between HLA genes and paranoid disorders. Delusional disorder and paranoid schizophrenia may share similar etiologic mechanisms. This preliminary observation may help our understanding of the genetic basis of these paranoid disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370605100602","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T18:56:41Z","timestamp":1484247401000},"page":"342-349","source":"Crossref","is-referenced-by-count":16,"title":["Genetic Associations between Delusional Disorder and Paranoid Schizophrenia: A Novel Etiologic Approach"],"prefix":"10.1177","volume":"51","author":[{"given":"Monojit","family":"Debnath","sequence":"first","affiliation":[{"name":"Formerly, Senior Research Fellow, Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, WB, India; Now, Postdoctoral Fellow, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujit K","family":"Das","sequence":"additional","affiliation":[{"name":"Professor and Head, Department of Psychiatry, North Bengal Medical College and Hospital, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmal K","family":"Bera","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Psychiatry, North Bengal Medical College and Hospital, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitta R","family":"Nayak","sequence":"additional","affiliation":[{"name":"Systems' Engineer and Head, Computer Centre, North Bengal Medical College and Hospital, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapas K","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Reader, Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, WB, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"bibr1-070674370605100602","first-page":"7","volume":"2","author":"Fujinawa A.","year":"1981","journal-title":"Clin Psychopathol"},{"key":"bibr2-070674370605100602","first-page":"91","volume-title":"Troublesome disguises: Underdiagnosed psychiatric syndromes","author":"Munro A.","year":"1997"},{"key":"bibr3-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/7.4.594"},{"key":"bibr4-070674370605100602","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1987","edition":"3"},{"key":"bibr5-070674370605100602","first-page":"217","volume-title":"Schizophrenia and aging","author":"Roth M.","year":"1987"},{"key":"bibr6-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1177\/070674378803300301"},{"key":"bibr7-070674370605100602","first-page":"651","volume-title":"New Oxford text book of psychiatry. Volume 1","author":"Munro A.","year":"2003"},{"key":"bibr8-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.147.5.524"},{"key":"bibr9-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(85)90069-0"},{"key":"bibr10-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780300059007"},{"key":"bibr11-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1159\/000132172"},{"key":"bibr12-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.1.1.117"},{"key":"bibr13-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072213"},{"key":"bibr14-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308193290808"},{"key":"bibr15-070674370605100602","first-page":"998","volume":"24","author":"Denburg SD","year":"1997","journal-title":"J Rheumatol"},{"key":"bibr16-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1007\/BF02190280"},{"key":"bibr17-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1177\/070674370505000507"},{"key":"bibr18-070674370605100602","first-page":"296","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","edition":"4"},{"key":"bibr19-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"bibr20-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"bibr21-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"bibr22-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1974.tb00230.x"},{"key":"bibr23-070674370605100602","unstructured":"Cavalli-Sforza LL, Bodmer WF. The genetics of human populations. San Francisco (CA): Freemann and Co; 1971. p 559\u201361."},{"key":"bibr24-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00022-0"},{"key":"bibr25-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-287"},{"key":"bibr26-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-325"},{"key":"bibr27-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.125.1.25"},{"key":"bibr28-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700034036"},{"key":"bibr29-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.110.469.818"},{"key":"bibr30-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.138.6.498"},{"key":"bibr31-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1159\/000153604"},{"key":"bibr32-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1983.tb01190.x"},{"key":"bibr33-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780020121014"},{"key":"bibr34-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(90)90091-I"},{"key":"bibr35-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.7.1173"},{"key":"bibr36-070674370605100602","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.40.s25"},{"key":"bibr37-070674370605100602","first-page":"1064","volume-title":"HLA 1991. Proceedings of the 11th International Histocompatibility Workshop and Conference. Volume 1","author":"Imanishi T","year":"1992"},{"key":"bibr38-070674370605100602","first-page":"121","volume-title":"Recent advances of animal science research. Voumel 1","author":"Mandal BB","year":"2000"},{"key":"bibr39-070674370605100602","first-page":"170","volume":"101","author":"Chaudhuri TK","year":"1995","journal-title":"Ind J Med Res"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370605100602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370605100602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:10:07Z","timestamp":1777392607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/070674370605100602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1177\/070674370605100602"],"URL":"https:\/\/doi.org\/10.1177\/070674370605100602","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}