{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:40:30Z","timestamp":1792035630787,"version":"4.4.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We previously found that 46% of the first 1450 outpatients with depression participating in the multicentre Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project qualified for the designation of anxious depression. This study was designed to replicate and extend our initial findings in a subsequent, larger cohort of outpatient STAR*D participants with nonpsychotic major depressive disorder (MDD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Baseline clinical and sociodemographic data were collected on 2337 consecutive STAR*D participants. A baseline 17-item Hamilton Depression Rating Scale Anxiety-Somatization factor score of 7 or higher was designated as anxious depression. We identified concurrent Axis I disorders with the Psychiatric Diagnostic Screening Questionnaire (PDSQ), using a 90% specificity threshold. Depressive symptoms were assessed by clinical telephone interview with the 30-item Inventory of Depressive Symptomatology\u2013Clinician-Rated (IDS-C30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The prevalence of anxious depression in this population was 45.1%. Patients with anxious MDD were significantly more likely to be in primary care settings and to be women, nonsingle, unemployed, Hispanic, less educated, and suffering from severe depression, both before and after adjustment for overall depression severity. Patients with anxious depression were significantly more likely to meet PDSQ thresholds for generalized anxiety disorder, panic disorder, obsessive\u2013compulsive disorder, posttraumatic stress disorder, agoraphobia, hypochondriasis, and somatoform disorder, both before and after adjusting for baseline depression severity. Individuals with anxious depression were also significantly less likely to endorse IDS-C30 items concerning atypical features and were significantly more likely to endorse items concerning melancholic-endogenous depression features, both before and after adjusting for baseline depression severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study clearly replicates our previous STAR*D findings and supports the notion that anxious depression may be a valid diagnostic subtype of MDD, with distinct psychiatric comorbidities and clinical and sociodemographic features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370605101304","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:35:42Z","timestamp":1483648542000},"page":"823-835","source":"Crossref","is-referenced-by-count":161,"title":["What Clinical and Symptom Features and Comorbid Disorders Characterize Outpatients with Anxious Major Depressive Disorder: A Replication and Extension"],"prefix":"10.1177","volume":"51","author":[{"given":"Maurizio","family":"Fava","sequence":"first","affiliation":[{"name":"Associate Chief of Psychiatry for Clinical Research, Massachusetts General Hospital, Boston, Massachusetts; Director, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts; Professor of Psychiatry, Harvard Medical School, Boston, Massachussets"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A John","family":"Rush","sequence":"additional","affiliation":[{"name":"Vice Chair, Department of Clinical Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas; Professor, Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E","family":"Alpert","sequence":"additional","affiliation":[{"name":"Associate Director, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl N","family":"Carmin","sequence":"additional","affiliation":[{"name":"Associate Professor, Stress & Anxiety Disorders Clinic, University of Illinois at Chicago, Chicago, Illinois; Director, Stress & Anxiety Disorders Clinic, University of Illinois at Chicago, Chicago, Illinois; Director, Cognitive Behavior Therapy Program, University of Illinois at Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GK","family":"Balasubramani","sequence":"additional","affiliation":[{"name":"Research Associate, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Wisniewski","sequence":"additional","affiliation":[{"name":"Associate Professor, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania; Deputy Director, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania; Associate Dean for Research, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhukar H","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Professor of Psychiatry, Mood Disorders Research Program and Clinic, The University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, Texas; Director, Mood Disorders Research Program and Clinic, The University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M","family":"Biggs","sequence":"additional","affiliation":[{"name":"Associate Professor, The University of Texas Southwestern Medical Center, Department of Psychiatry and Department of Family and Community Medicine, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Shores-Wilson","sequence":"additional","affiliation":[{"name":"Associate Professor, The University of Texas Southwestern Medical Center, Department of Psychiatry and Department of Family and Community Medicine, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"bibr1-070674370605101304","first-page":"8","volume":"44","author":"Fawcett J","year":"1983","journal-title":"J Clin Psychiatry"},{"key":"bibr2-070674370605101304","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.8.1257"},{"key":"bibr3-070674370605101304","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-0327(84)90009-0","volume":"6","author":"VanValkenburg 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