{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:50:15Z","timestamp":1792504215186,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess whether comorbid attention-deficit hyperactivity disorder (ADHD) influences response to treatment in young patients with acute mania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a metaanalysis of 5 open trials of 100, 35, 41, 60, and 37 children and adolescents. The pooled group included 273 children and adolescents with bipolar disorder (BD), divided into 2 subgroups: those with ( n = 132), and those without ( n = 141), ADHD comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was a moderate and significant reduction in relative risk (RR) favouring treatment response in children and adolescents with BD but without ADHD comorbidity (RR 0.822; 95%CI, 0.69 to 0.97; P = 0.021). The negative effect of ADHD comorbidity on treatment response was more significant in studies including adolescents only or subjects with BD I only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that children and adolescents with BD and ADHD tend to be less responsive to drugs used in treatment of acute mania.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370705200507","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T14:18:25Z","timestamp":1484230705000},"page":"323-328","source":"Crossref","is-referenced-by-count":38,"title":["Comorbidity with ADHD Decreases Response to Pharmacotherapy in Children and Adolescents with Acute Mania: Evidence from a Metaanalysis"],"prefix":"10.1177","volume":"52","author":[{"given":"Ang\u00e8le","family":"Consoli","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Child and Adolescent Psychiatry, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Universit\u00e9 Pierre et Marie Curie, Paris, France; and CNRS FRE 2987, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anissa","family":"Bouzamondo","sequence":"additional","affiliation":[{"name":"Clinical Lecturer, Department of Pharmacology, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Universit\u00e9 Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Guil\u00e9","sequence":"additional","affiliation":[{"name":"Clinical Associate Professor, Department of Psychiatry, Universit\u00e9 de Montreal, Montreal, Quebec; Assistant Professor of Psychiatry, Mc Gill University, Montreal, Quebec"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lechat","sequence":"additional","affiliation":[{"name":"Professor and Head, Department of Pharmacology, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Universit\u00e9 Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cohen","sequence":"additional","affiliation":[{"name":"Professor and Head, Department of Child and Adolescent Psychiatry, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00e9tri\u00e8re, Universit\u00e9 Pierre et Marie Curie, Paris, France; and CNRS FRE 2987, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"bibr1-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000170554.23422.c1"},{"key":"bibr2-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199504000-00012"},{"key":"bibr3-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199405000-00002"},{"key":"bibr4-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.5.459"},{"key":"bibr5-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830050073012"},{"key":"bibr6-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1207\/s15374424jccp3402_13"},{"key":"bibr7-070674370705200507","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0805"},{"key":"bibr8-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00213-4"},{"key":"bibr9-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00067-2"},{"key":"bibr10-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/01.CHI.0000070247.24125.24"},{"key":"bibr11-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.05.017"},{"key":"bibr12-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199908000-00011"},{"key":"bibr13-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200210000-00012"},{"key":"bibr14-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2004.14.593"},{"key":"bibr15-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1097\/01.CHI.0000046830.95464.33"},{"key":"bibr16-070674370705200507","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.126.7.983"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370705200507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370705200507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:10:41Z","timestamp":1777392641000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/070674370705200507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1177\/070674370705200507"],"URL":"https:\/\/doi.org\/10.1177\/070674370705200507","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}