{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:11:35Z","timestamp":1790788295244,"version":"4.1.0"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2008,3]]},"abstract":"\n Objective:<\/jats:title>\n As an extension of our previous observation, relating a serotonin transporter gene-linked promoter region (5-HTTLPR) diallelic functional polymorphism (short [S] and long [L] alleles) to the risk of post-stroke major depression (PSD), this study investigated the role of 2 other functional polymorphisms of the serotonin transporter gene (5-HTT) in the same sample of subjects with PSD.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n In a clinical sample of 26 patients with PSD and 25 unrelated nondepressed stroke patients of Caucasian descent, we examined the frequencies of a functional single nucleotide variant (A\/G) within the promoter region (rs25531) and located in L (16-repeat) and S (14-repeat) alleles of 5-HTTLPR, and a variable number tandem repeat (VNTR) polymorphism in intron 2.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n There were significant intergroup differences in the allelic frequencies of 5-HTTLPR\/rs25531 (S\n A<\/jats:sub>\n , L\n A<\/jats:sub>\n , and L\n G<\/jats:sub>\n ) ( P < 0.05) and in the combined frequencies of lower-expressing alleles (S\n A<\/jats:sub>\n and L\n G<\/jats:sub>\n ) and higher-expressing alleles (L\n A<\/jats:sub>\n ) ( P < 0.025) between subjects with PSD and nondepressed stroke. However, the differences in the combined frequencies of lower-expressing (S\n A<\/jats:sub>\n \/S\n A<\/jats:sub>\n , S\n A<\/jats:sub>\n \/L\n G<\/jats:sub>\n , and L\n G<\/jats:sub>\n \/L\n G<\/jats:sub>\n ), intermediate-expressing (S\n A<\/jats:sub>\n \/L\n A<\/jats:sub>\n and L\n A<\/jats:sub>\n \/L\n G<\/jats:sub>\n ), and higher-expressing (L\n A<\/jats:sub>\n \/L\n A<\/jats:sub>\n ) genotypes of 5-HTTLPR were not significant. Further, no significant intergroup differences were found in the allelic and genotypic frequencies of the intron 2 VNTR.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n These findings strengthen the support for an association between PSD and lower-expressing alleles of 5-HTTLPR.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/070674370805300310","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:19:58Z","timestamp":1500509998000},"page":"197-201","source":"Crossref","is-referenced-by-count":20,"title":["Extended Evaluation of Serotonin Transporter Gene Functional Polymorphisms in Subjects with Post-Stroke Depression"],"prefix":"10.1177","volume":"53","author":[{"given":"Rajamannar","family":"Ramasubbu","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Calgary, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Torben","family":"Bech-Hansen","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Calgary, Calgary, Alberta"},{"name":"Department of Surgery, Institute of Maternal and Child Health, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"bibr1-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30104"},{"key":"bibr2-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1007\/BF01276434"},{"key":"bibr3-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66062621.x"},{"key":"bibr4-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000150008.68473.62"},{"key":"bibr5-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.048"},{"key":"bibr6-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.18.1.96"},{"key":"bibr7-070674370805300310","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001789"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370805300310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674370805300310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:11:18Z","timestamp":1777392678000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/070674370805300310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1177\/070674370805300310"],"URL":"https:\/\/doi.org\/10.1177\/070674370805300310","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}