{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:07:41Z","timestamp":1789038461361,"version":"build-2803163510"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This paper describes the project design, demographics, clinical outcomes, and predictors at 6 months to 1 year of follow-up of the first 53 recruited subjects with first-episode mania from the Systematic Treatment Optimization Program for Early Mania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Survival analysis for recurrence of mood episodes showed that 46.7% of patients survived without a mood episode during 1-year of follow-up, and the mean time-to-mood event was 7.9 months. Earlier age of onset was the only variable that significantly predicted recurrence of mood episodes. When examined separately, the survival rates were 76% for a manic episode and 58.7% for a depressive episode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results suggest that recurrences are common after the first manic episode with more than one-half of the patients experiencing a mood event within 12 months. Aggressive treatment strategies aimed at preventing depressive episodes are needed in the management of early course BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674370905400208","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T16:13:38Z","timestamp":1484324018000},"page":"105-112","source":"Crossref","is-referenced-by-count":88,"title":["Course and Outcome after the First Manic Episode in Patients with Bipolar Disorder: Prospective 12-Month Data from the Systematic Treatment Optimization Program for Early Mania Project"],"prefix":"10.1177","volume":"54","author":[{"given":"Lakshmi N","family":"Yatham","sequence":"first","affiliation":[{"name":"Professor of Psychiatry, Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Kauer-Sant'Anna","sequence":"additional","affiliation":[{"name":"Clinical Fellow Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Bond","sequence":"additional","affiliation":[{"name":"Associate Professor of Psychiatry, Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond W","family":"Lam","sequence":"additional","affiliation":[{"name":"Professor of Psychiatry, Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Torres","sequence":"additional","affiliation":[{"name":"Associate Professor of Psychiatry, Mood Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"bibr1-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"bibr2-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.12.1322"},{"key":"bibr3-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01055.x"},{"key":"bibr4-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2004.00413.x"},{"key":"bibr5-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-72"},{"key":"bibr6-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.41.s184"},{"key":"bibr7-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00004711"},{"key":"bibr8-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.1.49"},{"key":"bibr9-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(00)00015-7"},{"key":"bibr10-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.220"},{"key":"bibr11-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.582"},{"key":"bibr12-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798006862"},{"key":"bibr13-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(97)00163-8"},{"key":"bibr14-070674370905400208","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.12.2099"},{"key":"bibr15-070674370905400208","first-page":"22","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"bibr16-070674370905400208","volume-title":"Diagnostic and statistical manual of mental disorders. 4th ed. 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