{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:39:33Z","timestamp":1784702373320,"version":"3.55.0"},"reference-count":64,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012466","name":"Mathison Centre for Mental Health Research and Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012466","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While antipsychotic medications are the mainstay of therapy for individuals with schizophrenia and psychotic disorders, their use is associated with adverse effects on physical health that require the attention and care of prescribers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used the ADAPTE process to adapt existing guideline recommendations from the National Institute for Health and Care Excellence (NICE) and Scottish Intercollegiate Guidelines Network (SIGN) guidelines on the dosing of antipsychotics and antipsychotic polypharmacy, screening for adverse effects of antipsychotics, and management of metabolic and extrapyramidal side effects to the Canadian context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Prescribers are encouraged to use the lowest effective dose and to avoid the routine use of multiple antipsychotics. Scheduled monitoring of body mass index, waist circumference, blood pressure, glucose, lipids, prolactin, electrocardiograms, and extrapyramidal symptoms is recommended. Lifestyle interventions are recommended to mitigate antipsychotic-induced weight gain. Prescribers should follow Canadian guidelines on the treatment of obesity, dyslipidemia, and diabetes. Recommendations on antipsychotic drug choice are made for users particularly concerned about extrapyramidal symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Careful monitoring and attention by prescribers may mitigate adverse effects associated with antipsychotic medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0706743717719898","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T12:15:31Z","timestamp":1500552931000},"page":"673-683","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Physical Health and Drug Safety in Individuals with Schizophrenia"],"prefix":"10.1177","volume":"62","author":[{"given":"Tamara","family":"Pringsheim","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Psychiatry, Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Urness","sequence":"additional","affiliation":[{"name":"Clinical Department Head, Addiction and Mental Health, Central Zone, Alberta Health Services, Edmonton, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Teehan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Clinical Neurosciences, University of Calgary, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"bibr2-0706743717719898","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090449"},{"key":"bibr3-0706743717719898","first-page":"178","author":"National Institute for Health and Care Excellence","year":"2014","journal-title":"National Clinical Guideline Number"},{"key":"bibr4-0706743717719898","first-page":"155","author":"National Institute for Health and Care Excellence","year":"2013","journal-title":"National Clinical Guideline Number"},{"key":"bibr5-0706743717719898","first-page":"120","author":"National Institute for Health and Care Excellence","year":"2011","journal-title":"NICE Clinical Guideline Number"},{"key":"bibr6-0706743717719898","unstructured":"Scottish Intercollegiate Guidelines Network. 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