{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:37:47Z","timestamp":1781242667066,"version":"3.54.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011338","name":"AstraZeneca Schweiz","doi-asserted-by":"publisher","award":["DC-990-205"],"award-info":[{"award-number":["DC-990-205"]}],"id":[{"id":"10.13039\/100011338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>It has been proposed that different stages of the bipolar disorder might have distinct neurobiological changes. However, the evidence for this has not been consistent, as the studies in early stages of the illness are limited by small sample sizes. The purpose of this study was to investigate the gray matter volume changes in bipolar patients who recently recovered from their first episode of mania (FEM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using a whole-brain voxel-based analysis, we compared the regional gray matter volumes of 61 bipolar patients who have recovered from their FEM in the past 3 months with 43 age- and gender-matched healthy participants. We also performed a series of subgroup analyses to determine the effects of hospitalization during the FEM, history of depressive episodes, and exposure to lithium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No statistically significant difference was found between gray matter volumes of FEM patients and healthy participants, even at a more liberal threshold ( P &lt; 0.001, uncorrected for multiple comparisons). Voxel-based subgroup analyses did not reveal significant gray matter differences except for a trend toward decreased gray matter volume in left lateral occipital cortex ( P &lt; 0.001, uncorrected) in patients with a previous history of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study represents the largest structural neuroimaging investigation of FEM published to date. Early stage of bipolar disorder was not found to be associated with significant gray matter volume changes. Our findings suggest that there might be a window of opportunity for early intervention strategies to prevent or delay neuroprogression in bipolar disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0706743720927827","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T06:41:04Z","timestamp":1589784064000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Preservation of Gray Matter Volume in Early Stage of Bipolar Disorder: A Case for Early Intervention: Pr\u00e9servation du volume de mati\u00e8re grise au stade pr\u00e9coce du trouble bipolaire: un cas pour intervention pr\u00e9coce"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-6025","authenticated-orcid":false,"given":"Kamyar","family":"Keramatian","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Saraf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi N.","family":"Yatham","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"bibr1-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13081008"},{"key":"bibr2-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-010-9197-8"},{"key":"bibr3-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.31"},{"key":"bibr4-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00284.x"},{"key":"bibr5-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.11.1841"},{"key":"bibr6-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby047"},{"key":"bibr7-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1296"},{"key":"bibr8-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.033"},{"key":"bibr9-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e318184ff48"},{"key":"bibr10-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.281"},{"key":"bibr11-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00896.x"},{"key":"bibr12-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.042"},{"key":"bibr13-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"bibr14-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1177\/070674370905400208"},{"key":"bibr15-0706743720927827","first-page":"2022","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"bibr16-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"bibr17-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"bibr18-0706743720927827","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"bibr19-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"bibr20-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00219.x"},{"key":"bibr21-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00672.x"},{"key":"bibr22-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12025"},{"key":"bibr23-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"bibr24-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1109\/42.668698"},{"key":"bibr25-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm184"},{"key":"bibr26-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"bibr27-0706743720927827","unstructured":"Andersson JL, Jenkinson M, Smith S. Non-linear registration aka spatial normalisation FMRIB technical report TR07JA2. Oxford, United Kingdom: FMRIB Centre; 2007 [accessed 2019 October 17]. https:\/\/www.fmrib.ox.ac.uk\/datasets\/techrep\/tr07ja2\/tr07ja2.pdf"},{"key":"bibr28-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"bibr29-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"bibr30-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.09.074"},{"key":"bibr31-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.020"},{"key":"bibr32-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01000.x"},{"key":"bibr33-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.73"},{"key":"bibr34-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009498"},{"key":"bibr35-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.001"},{"key":"bibr36-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.08.029"},{"key":"bibr37-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01024.x"},{"key":"bibr38-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12437"},{"key":"bibr39-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01023.x"},{"key":"bibr40-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.41"},{"key":"bibr41-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.029"},{"key":"bibr42-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr134"},{"key":"bibr43-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.12.022"},{"key":"bibr44-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90098-X"},{"key":"bibr45-0706743720927827","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.322"},{"key":"bibr46-0706743720927827","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.07m03745"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0706743720927827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0706743720927827","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0706743720927827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:14:19Z","timestamp":1777392859000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0706743720927827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,18]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1177\/0706743720927827"],"URL":"https:\/\/doi.org\/10.1177\/0706743720927827","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,18]]}}}