{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:41:00Z","timestamp":1788450060618,"version":"build-2803163510"},"reference-count":63,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>A substantial proportion of severely ill patients with obsessive-compulsive disorder (OCD) do not respond to serotonin reuptake inhibitors (SRIs) and are unable to practice cognitive behavioral therapy (CBT) on an out-patient basis. We report the short-term (at discharge) and long-term (up to 2 years) outcome of a multimodal inpatient treatment program that included therapist-assisted intensive CBT with adjunctive pharmacotherapy for severely ill OCD patients who are often resistant to SRIs and are either unresponsive or unable to practice outpatient CBT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 420 patients, admitted between January 2012 and December 2017 were eligible for the analysis. They were evaluated using the Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive Compulsive Scale (YBOCS), and the Clinical Global Impression (CGI) scale. All patients received 4 to 5 therapist-assisted CBT sessions per week along with standard pharmacotherapy. Naturalistic follow-up information at 3, 6, 12, and 24 months were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At baseline, patients were mostly severely ill (YBOCS = 29.9 \u00b1 4.5) and nonresponsive to \u22652 SRIs (83%). Mean duration of inpatient stay was 42.7 \u00b1 25.3 days. At discharge, there was a significant decline in the mean YBOCS score (29.9 \u00b1 4.5 vs. 18.1 \u00b1 7.7, P &lt; .001, Cohen\u2019s d = 1.64); 211\/420 (50%) were responders (\u226535% YBOCS reduction and CGI-I\u22642) and an additional 86\/420 (21%) were partial responders (25% to 35% YBOCS reduction and CGI-I\u22643). Using latent class growth modeling of the follow-up data, 4 distinct classes were identified, which include \u201cremitters\u201d (14.5%), \u201cresponders\u201d (36.5%), \u201cminimal responders\u201d (34.7%), and \u201cnonresponders\u201d (14.6%). Shorter duration of illness, better insight, and lesser contamination\/washing symptoms predicted better response in both short- and long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intensive, inpatient-based care for OCD may be an effective option for patients with severe OCD and should be considered routinely in those who do not respond with outpatient treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0706743720927830","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T07:16:47Z","timestamp":1590477407000},"page":"779-789","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Long-term Outcomes of Intensive Inpatient Care for Severe, Resistant Obsessive-Compulsive Disorder: R\u00e9sultats \u00e0 long terme de soins intensifs \u00e0 des patients hospitalis\u00e9s pour un trouble obsessionnel-compulsif grave et r\u00e9sistant"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-6414","authenticated-orcid":false,"given":"Srinivas","family":"Balachander","sequence":"first","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakash","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Hazari","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"},{"name":"Department of Clinical Psychology, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Anand","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"},{"name":"Department of Clinical Psychology, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Manjula","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"},{"name":"Department of Clinical Psychology, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulomi M.","family":"Sudhir","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"},{"name":"Department of Clinical Psychology, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish V.","family":"Cherian","sequence":"additional","affiliation":[{"name":"Department of Psychiatric Social Work, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardhanan C.","family":"Narayanaswamy","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. S.","family":"Jaisoorya","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Bada","family":"Math","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thennarasu","family":"Kandavel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, NIMHANS, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam Sundar","family":"Arumugham","sequence":"additional","affiliation":[{"name":"Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Science (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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