{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:17:04Z","timestamp":1790299024657,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>La schizophr\u00e9nie tr\u00e8s pr\u00e9coce (STP) est une forme rare (1\/40000), grave et neurod\u00e9veloppementale de schizophr\u00e9nie d\u00e9butant avant 13 ans. Les comorbidit\u00e9s et atteintes associ\u00e9es sp\u00e9cifiques des STP \u00e9tant peu \u00e9tudi\u00e9es, l\u2019objectif de notre \u00e9tude a \u00e9t\u00e9 de les \u00e9valuer sur le plan psychiatrique, neurod\u00e9veloppemental et somatique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>M\u00e9thode:<\/jats:title>\n                    <jats:p>Il s\u2019agit d\u2019une \u00e9tude ancillaire du protocole GenAuDiss. Un entretien psychiatrique standardis\u00e9 (K-SADS-PL DSM5) et un bilan neuropsychologique (WISC-V\/WAIS-IV) ont \u00e9t\u00e9 effectu\u00e9s chez les patients atteints de STP ainsi qu\u2019une anamn\u00e8se concernant la grossesse, la p\u00e9rinatalit\u00e9, le d\u00e9veloppement, la biographie et les ant\u00e9c\u00e9dents m\u00e9dicaux et psychiatriques, personnels et familiaux.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>R\u00e9sultats:<\/jats:title>\n                    <jats:p>20 sujets ont \u00e9t\u00e9 inclus. L\u2019\u00e2ge moyen de d\u00e9but du trouble \u00e9tait de 8,90 ans (+\/\u22122,30). Les comorbidit\u00e9s psychiatriques (DSM5) \u00e9taient le Trouble D\u00e9ficitaire de l\u2019Attention avec Hyperactivit\u00e9 (15\/20 patients), les troubles anxieux (14\/20) et le Trouble du Spectre de l\u2019Autisme (13\/20). Le QI moyen \u00e9tait de 70,26 (+\/\u221218,09). Un retard de langage et une rupture de parcours scolaire \u00e9taient not\u00e9s chez 18\/20 patients. Enfin, l\u2019affection somatique principale associ\u00e9e \u00e9tait l\u2019asthme (15\/20 patients).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Nous avons mis en \u00e9vidence chez nos patients atteints de STP une fr\u00e9quence \u00e9lev\u00e9e de comorbidit\u00e9s dont au moins un trouble psychiatrique syst\u00e9matique. Or, bien que la schizophr\u00e9nie infantile soit une pathologie de pronostic s\u00e9v\u00e8re impactant le patient, sa famille et la soci\u00e9t\u00e9, sa prise en charge demeure essentiellement symptomatique. En pratique clinique, il appara\u00eet n\u00e9cessaire de rechercher syst\u00e9matiquement ces comorbidit\u00e9s et de les prendre en charge pour am\u00e9liorer la qualit\u00e9 globale des soins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0706743721990822","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T06:17:05Z","timestamp":1613197025000},"page":"1042-1050","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Atteintes Neurod\u00e9veloppementales, Comorbidit\u00e9s Psychiatriques Et Pathologies Associ\u00e9es Chez Des Patients Atteints de Schizophr\u00e9nie Tr\u00e8s Pr\u00e9coce Avec Sympt\u00f4mes Autistiques Pr\u00e9morbides."],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-9096","authenticated-orcid":false,"given":"A","family":"Fernandez","sequence":"first","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, H\u00f4pitaux P\u00e9diatriques de Nice CHU-LENVAL, 57 avenue de la Californie, Nice, France"},{"name":"Universit\u00e9 C\u00f4te d'Azur, CoBTek, FRIS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pasquet-Levy","sequence":"additional","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, H\u00f4pitaux P\u00e9diatriques de Nice CHU-LENVAL, 57 avenue de la Californie, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Laure","sequence":"additional","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, H\u00f4pitaux P\u00e9diatriques de Nice CHU-LENVAL, 57 avenue de la Californie, Nice, France"},{"name":"Universit\u00e9 C\u00f4te d'Azur, CoBTek, FRIS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Th\u00fcmmler","sequence":"additional","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, H\u00f4pitaux P\u00e9diatriques de Nice CHU-LENVAL, 57 avenue de la Californie, Nice, France"},{"name":"Universit\u00e9 C\u00f4te d'Azur, CoBTek, FRIS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Askenazy","sequence":"additional","affiliation":[{"name":"Service Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, H\u00f4pitaux P\u00e9diatriques de Nice CHU-LENVAL, 57 avenue de la Californie, Nice, France"},{"name":"Universit\u00e9 C\u00f4te d'Azur, CoBTek, FRIS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"bibr1-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2019.08.017"},{"key":"bibr2-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"bibr3-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.3.361"},{"key":"bibr4-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.07.006"},{"key":"bibr5-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033472"},{"key":"bibr6-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00429-2"},{"key":"bibr7-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.12.1187"},{"key":"bibr8-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2019.08.007"},{"key":"bibr9-0706743721990822","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01137"},{"key":"bibr10-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18111275"},{"key":"bibr11-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.23"},{"key":"bibr12-0706743721990822","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236241"},{"key":"bibr13-0706743721990822","doi-asserted-by":"crossref","first-page":"e023330","DOI":"10.1136\/bmjopen-2018-023330","volume":"8","author":"Fernandez A","year":"2018","journal-title":"BMJ Open"},{"key":"bibr14-0706743721990822","unstructured":"Th\u00fcmmler S, Askenazy F. 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