{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:07:02Z","timestamp":1793239622042,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014405","name":"Centre for Addiction and Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Collaborative care (CC) could improve outcomes in primary care patients with common mental conditions. We assessed the effectiveness of a transdiagnostic model of telephone-based CC (tCC) delivered by lay providers to primary care patients with depression, anxiety, or at-risk drinking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PARTNERS was a pragmatic trial in 502 primary care adults presenting with depressive symptoms, anxiety symptoms, or at-risk drinking randomized to (1) usual care by primary care providers (PCPs) enhanced with the results of computer-assisted telephone-based assessments (at baseline and 4, 8, and 12 months later) (enhanced usual care [eUC]) or (2) tCC consisting of eUC plus frequent telephone coaching and psychoeducation provided by mental health technicians who also communicated to the PCP recommendations from a psychiatrist for evidence-based pharmacotherapy, psychotherapy, or, when indicated, referrals to mental health services. The primary analysis compared the change on the 9-item Patient Health Questionnaire (PHQ-9) in participants presenting with depression ( n\u2009=\u2009366) randomized to tCC versus eUC. Secondary analyses compared changes on the Generalized Anxiety Disorder-7 scale (GAD-7) in those presenting with anxiety ( n\u2009=\u2009298); or change in the number of weekly drinks in those presenting with at-risk drinking ( n\u2009=\u2009176).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no treatment or time\u00d7treatment effects between tCC and eUC on PHQ-9 scores for patients with depression during the 12-month follow-up. However, there was a treatment effect (tCC\u2009&gt;\u2009eUC) on GAD-7 scores in those with anxiety and a time\u00d7treatment interaction effect on the number of weekly drinks (tCC\u2009&gt;\u2009eUC) in those with at-risk drinking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implementing transdiagnostic tCC for common mental disorders using lay providers appears feasible in Canadian primary care. While tCC was not better than eUC for depression, there were some benefits for those with anxiety or at-risk drinking. Future studies will need to confirm whether tCC differentially benefits patients with depression, anxiety, or at-risk drinking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437231156243","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T02:10:55Z","timestamp":1677636655000},"page":"732-744","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["A Collaborative-Care Telephone-Based Intervention for Depression, Anxiety, and at-Risk Drinking in Primary Care: The PARTNERs Randomized Clinical Trial"],"prefix":"10.1177","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-5750","authenticated-orcid":false,"given":"M.","family":"Ishrat Husain","sequence":"first","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Rodie","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Perivolaris","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Sanches","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Crawford","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle P.","family":"Fitzgibbon","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-1992","authenticated-orcid":false,"given":"Andrea","family":"Levinson","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Geist","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8115-7437","authenticated-orcid":false,"given":"Paul","family":"Kurdyak","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Group Health Centre, Sault Ste, Marie, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Oslin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pennsylvania and the Department of Veteran Affairs, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadiya","family":"Sunderji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Waypoint Centre for Mental Health Care, Penetanguishene, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-6450","authenticated-orcid":false,"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PARTNERs Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"bibr1-07067437231156243","unstructured":"Global health estimates: Leading causes of death [Internet]. [cited 2021 Oct 21]. Available from: https:\/\/www.who.int\/data\/maternal-newborn-child-adolescent-ageing\/advisory-groups\/gama\/gama-advisory-group-members."},{"key":"bibr2-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1080\/08039480802141129"},{"key":"bibr3-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2014.05.002"},{"key":"bibr4-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20388"},{"key":"bibr5-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20040454"},{"key":"bibr6-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.04.014"},{"key":"bibr7-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006525.pub2"},{"key":"bibr8-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.8.914"},{"key":"bibr9-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1370\/afm.143"},{"key":"bibr10-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1177\/0706743719895342"},{"key":"bibr11-07067437231156243","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-12-200406150-00012"},{"key":"bibr12-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1177\/0706743717748884"},{"key":"bibr13-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1842"},{"key":"bibr14-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106284"},{"key":"bibr15-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.140.6.734"},{"key":"bibr16-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"bibr17-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"bibr18-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1097\/00004479-200604000-00011"},{"key":"bibr19-07067437231156243","volume-title":"Alcohol and health in Canada: a summary of evidence and guidelines for low-risk drinking [Internet]","author":"Butt P"},{"key":"bibr20-07067437231156243","volume":"3","author":"Chibanda D","year":"2016","journal-title":"Glob Ment Health (Camb)"},{"key":"bibr21-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61508-5"},{"key":"bibr22-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1111\/jar.12006"},{"key":"bibr23-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1186\/s13033-019-0320-9"},{"key":"bibr24-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1002\/da.22239"},{"key":"bibr25-07067437231156243","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-6-200909150-00001"},{"key":"bibr26-07067437231156243","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.18m12483"},{"key":"bibr27-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12504"},{"key":"bibr28-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113598"},{"key":"bibr29-07067437231156243","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.567426"},{"key":"bibr30-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.21.2314"},{"issue":"2","key":"bibr31-07067437231156243","volume":"7","author":"Sunderji N","year":"2019","journal-title":"Can Med Assoc Open Access J"},{"key":"bibr32-07067437231156243","doi-asserted-by":"publisher","DOI":"10.2196\/10224"},{"key":"bibr33-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-016-3873-1"},{"key":"bibr34-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00083-3"},{"key":"bibr35-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.3379"},{"key":"bibr36-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30366-9"},{"key":"bibr37-07067437231156243","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.21r14034"},{"key":"bibr38-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.3947"},{"key":"bibr39-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.277609"},{"key":"bibr40-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1002\/da.20231"},{"key":"bibr41-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707001365"},{"key":"bibr42-07067437231156243","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170400296X"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437231156243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07067437231156243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437231156243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:15:08Z","timestamp":1777392908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07067437231156243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/07067437231156243"],"URL":"https:\/\/doi.org\/10.1177\/07067437231156243","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]}}}