{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:01:24Z","timestamp":1777521684413,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences, Mental Health and Addiction","doi-asserted-by":"publisher","award":["201209MOP-288050-BSB-29052"],"award-info":[{"award-number":["201209MOP-288050-BSB-29052"]}],"id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008021","name":"Bristol-Myers Squibb Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021138","name":"Lundbeck Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021138","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Childhood maltreatment is a potent enviromarker of risk for poor response to antidepressant medication (ADM). However, childhood maltreatment is a heterogeneous construct that includes distinct exposures that have distinct neurobiological and psychological correlates. The purpose of the current study is to examine the differential associations of emotional, physical, and sexual maltreatment to ADM outcome and to examine the unique role of anhedonia in driving poor response in patients with specific maltreatment histories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a multicentre clinical trial of major depression, 164 individuals were assessed for childhood emotional, physical, and sexual maltreatment with a contextual interview with independent, standardized ratings. All individuals received 8 weeks of escitalopram, with nonresponders subsequently also receiving augmentation with aripiprazole, with outcomes measured with depression rating scales and an anhedonia scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Greater severity of emotional maltreatment perpetrated by the mother was a significant and direct predictor of lower odds of week 16 remission (odds ratio [OR]\u2009=\u20091.68, P\u2009=\u20090.02). In contrast, the relations of paternal-perpetrated emotional maltreatment and physical maltreatment to week 16 remission were indirect, mediated through greater severity of anhedonia at week 8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identify emotional maltreatment as a specific early exposure that places patients at the greatest risk for nonremission following pharmacological treatment. Further, we suggest that anhedonia is a key symptom domain driving nonremission in patients with particular maltreatment histories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437231156255","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T02:28:49Z","timestamp":1676341729000},"page":"586-595","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report"],"prefix":"10.1177","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-8994","authenticated-orcid":false,"given":"Kate L.","family":"Harkness","sequence":"first","affiliation":[{"name":"Department of Psychology, Queen's University, Kingston, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakina J.","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Centre for Depression and Suicide Studies, St. Michael's Hospital, Toronto ON, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-4815","authenticated-orcid":false,"given":"Raegan","family":"Mazurka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Quilty","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-0546","authenticated-orcid":false,"given":"Rudolf","family":"Uher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University, Halifax, NS, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-171X","authenticated-orcid":false,"given":"Roumen V.","family":"Milev","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Queen's University, and Providence Care, Kingston, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benicio N.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada"},{"name":"Mood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-3042","authenticated-orcid":false,"given":"Sagar V.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Rotzinger","sequence":"additional","affiliation":[{"name":"Centre for Depression and Suicide Studies, St. Michael's Hospital, Toronto ON, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-7185","authenticated-orcid":false,"given":"Sidney H.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Centre for Depression and Suicide Studies, St. Michael's Hospital, Toronto ON, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-4669","authenticated-orcid":false,"given":"Raymond W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"bibr1-07067437231156255","unstructured":"World Health Organization. Depression and other common mental disorders: Global health estimates. January 3, 2017. https:\/\/www.who.int\/publications\/i\/item\/depression-global-health-estimates."},{"key":"bibr2-07067437231156255","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.4\/mhtrivedi"},{"key":"bibr3-07067437231156255","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803523635"},{"key":"bibr4-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19010020"},{"key":"bibr5-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11020335"},{"key":"bibr6-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110208"},{"key":"bibr7-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1037\/a0027665"},{"key":"bibr8-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.61"},{"key":"bibr9-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1159\/000453549"},{"key":"bibr10-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1177\/0963721416655883"},{"key":"bibr11-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000521"},{"key":"bibr12-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.04.007"},{"key":"bibr13-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2018.12.017"},{"key":"bibr14-07067437231156255","volume-title":"Current topics in behavioral neurosciences","author":"Harkness KL","year":"2022"},{"key":"bibr15-07067437231156255","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.744690"},{"key":"bibr16-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.01.011"},{"key":"bibr17-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.10.026"},{"key":"bibr18-07067437231156255","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.18m12202"},{"key":"bibr19-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0785-x"},{"key":"bibr20-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy083"},{"key":"bibr21-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718002441"},{"key":"bibr22-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171900268X"},{"issue":"20","key":"bibr23-07067437231156255","first-page":"22","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"bibr24-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"bibr25-07067437231156255","doi-asserted-by":"publisher","DOI":"10.3758\/BF03203630"},{"key":"bibr26-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00451-7"},{"key":"bibr27-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1994.tb01284.x"},{"key":"bibr28-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.07.062"},{"key":"bibr29-07067437231156255","volume-title":"Introduction to mediation, moderation, and conditional process analysis: a regression-based approach","author":"Hayes AF","year":"2018","edition":"2"},{"key":"bibr30-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1177\/0956797613502676"},{"key":"bibr31-07067437231156255","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-014-0481-z"},{"key":"bibr32-07067437231156255","doi-asserted-by":"publisher","DOI":"10.2753\/MTP1069-6679190202"},{"key":"bibr33-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2016.05.013"},{"key":"bibr34-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01003-8"},{"key":"bibr35-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2273"},{"key":"bibr36-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.jesp.2011.11.009"},{"key":"bibr37-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.134"},{"key":"bibr38-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000070"},{"key":"bibr39-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2020.101860"},{"key":"bibr40-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.06.021"},{"key":"bibr41-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.09.065"},{"key":"bibr42-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000178"},{"key":"bibr43-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1159\/000330002"},{"key":"bibr44-07067437231156255","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.0097"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437231156255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07067437231156255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437231156255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:15:09Z","timestamp":1777392909000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/07067437231156255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/07067437231156255"],"URL":"https:\/\/doi.org\/10.1177\/07067437231156255","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]}}}