{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:23:34Z","timestamp":1785878614837,"version":"3.56.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Instituto Nacional de Ci\u00eancia e Tecnologia Transl"],"award-info":[{"award-number":["Instituto Nacional de Ci\u00eancia e Tecnologia Transl"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP; 2020\/12110-9"],"award-info":[{"award-number":["FAPESP; 2020\/12110-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The treatment of bipolar depression remains challenging due to the limited effective and safe therapeutic options available; thus, developing newer treatments that are effective and well tolerable is an urgent unmet need. The objective of the present trial was to test 150 to 300\u2005mg\/day of cannabidiol as an adjunctive treatment for bipolar depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A randomized, double-blind, placebo-controlled pilot study to assess the efficacy of adjunctive cannabidiol in bipolar depression was used. Efficacy parameters were changes in the Montgomery-\u00c5sberg Depression Rating Scale (MADRS) from baseline to week 8. Secondary outcomes included response and remission rates, changes in anxiety and psychotic symptoms, and changes in functioning. Patients continued double-blind treatment until week 12 to monitor for adverse effects, laboratory analysis, and manic symptoms. Study registry: NCT03310593.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 35 participants were included. MADRS scores significantly decreased from baseline to the endpoint (placebo, \u221214.56; cannabidiol, \u221215.38), but there was no significant difference between the groups. Similarly, there were no other significant effects on the secondary outcomes. However, an exploratory analysis showed a significant effect of cannabidiol 300\u2005mg\/day in reducing MADRS scores from week 2 to week 8 (placebo, \u22126.64; cannabidiol, \u221213.72). There were no significant differences in the development of manic symptoms or any other adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cannabidiol did not show significantly higher adverse effects than placebo. Despite the negative finding on the primary outcome, an exploratory analysis suggested that cannabidiol should be further studied in bipolar depression in higher doses of at least 300\u2005mg\/day and under research designs that could better control for high placebo response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437231209650","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T04:26:18Z","timestamp":1698985578000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Cannabidiol as an Adjunctive Treatment for Acute Bipolar Depression: A Pilot Study: Le cannabidiol comme traitement d'appoint de la d\u00e9pression bipolaire aigu\u00eb : une \u00e9tude pilote"],"prefix":"10.1177","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-6749","authenticated-orcid":false,"given":"Jairo Vin\u00edcius","family":"Pinto","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"},{"name":"Federal University of Santa Catarina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alexandre S.","family":"Crippa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavioural Sciences, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"},{"name":"National Institute for Science and Technology in Translational Medicine (INCT\u2013TM), CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keila Maria","family":"Ceres\u00e9r","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir\u00e9ia Fortes","family":"Vianna-Sulzbach","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rico de Moura","family":"Silveira J\u00fanior","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Santana da Rosa","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoella Guatimuzim","family":"Testa da Silva","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Henrique","family":"Hizo","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-7817","authenticated-orcid":false,"given":"Leonardo","family":"Sim\u00e3o Medeiros","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Santana de Oliveira","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana","family":"Bristot","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alline Cristina","family":"Campos","sequence":"additional","affiliation":[{"name":"National Institute for Science and Technology in Translational Medicine (INCT\u2013TM), CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil"},{"name":"Department of Pharmacology, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Silveira","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"National Institute for Science and Technology in Translational Medicine (INCT\u2013TM), CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil"},{"name":"Department of Pharmacology, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E. C.","family":"Hallak","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavioural Sciences, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"},{"name":"National Institute for Science and Technology in Translational Medicine (INCT\u2013TM), CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W.","family":"Zuardi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavioural Sciences, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"},{"name":"National Institute for Science and Technology in Translational Medicine (INCT\u2013TM), CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi N.","family":"Yatham","sequence":"additional","affiliation":[{"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Kapczinski","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"},{"name":"National Institute for Science and Technology in Translational Medicine (INCT\u2013TM), CNPq\/FAPESP\/CAPES, Ribeir\u00e3o Preto, Brazil"},{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-6230","authenticated-orcid":false,"given":"M\u00e1rcia","family":"Kauer-Sant\u2019Anna","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"},{"name":"Federal University of Rio Grande do Sul"},{"name":"Federal University of Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.12"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00505-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.12.1322"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2008.05.013"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12087"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02009"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/can.2019.0052"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17030325"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.15"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30290-X"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.18101191"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.06.006"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.06.002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1143-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.12.019"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40501-022-00265-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0706743719895195"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0667-2"},{"key":"e_1_3_3_22_2","volume-title":"Diagnostic and statistical manual of mental disorders\u202f: DSM-5","author":"APA","year":"2013","unstructured":"APA. Diagnostic and statistical manual of mental disorders\u202f: DSM-5. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.","edition":"5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(97)83297-X"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_3_3_26_2","unstructured":"Guy W. ECDEU assessment manual for psychopharmacology. Rockville MD: U.S. Department of Health Education and Welfare Public Health Service Alcohol Drug Abuse and Mental Health Administration National Institute of Mental Health Psychopharmacology Research Branch Division of Extramural Research Programs; 1976. DHEW publication no. (ADM) 76-338."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.18.1737"},{"issue":"1","key":"e_1_3_3_28_2","first-page":"23","article-title":"A rating scale for depression","author":"Hamilton M.","year":"1960","unstructured":"Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23(1):56-62.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-0179-3-5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb10566.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.03.065"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13853"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05823-w"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13305"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1754793"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488611798280924"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437231209650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07067437231209650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437231209650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:15:17Z","timestamp":1777392917000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07067437231209650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,3]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/07067437231209650"],"URL":"https:\/\/doi.org\/10.1177\/07067437231209650","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,3]]}}}